https://li01.tci-thaijo.org/index.php/JBAP/issue/feed 2026-09-02T23:53:52+07:00 Associate Professor Dr. Rattima Jeenapongsa jbap@nu.ac.th Open Journal Systems <p><span style="font-size: medium;"><strong>Journal of Basic and Applied Pharmacology</strong> <strong>(J Basic App Pharmacol) </strong>(former title: Thai Journal of Pharmacology) is a peer-reviewed journal publishing original research articles, reviews, case reports, letters to editors and commentaries on pharmacology and related fields, i.e. pharmacodynamics, pharmacokinetics, pharmacotherapeutics, toxicology, clinical pharmacology, molecular pharmacology, pharmacogenetics/pharmacogenomics, comparative pharmacology, safety pharmacology, systems pharmacology, pharmacoepidemiology and ethnopharmacology. The research article and review of all fields must be peer-reviewed by at least three reviewers. Thai Journal of Pharmacology has been abstracted and indexed by <strong>Thai Journal Citation Index (TCI - Tier 1)</strong> and <strong>ASEAN Citation Index (ACI)</strong>. The indexing in the TCI and ACI is continued with the <strong>Journal of Basic and Applied Pharmacology.</strong></span><span style="font-size: medium;"><strong><br /></strong></span></p> <p> </p> <p><span style="font-size: medium;"><strong>ISSN: 2774-0854 (Online)</strong></span></p> https://li01.tci-thaijo.org/index.php/JBAP/article/view/273004 2026-07-21T11:28:49+07:00 Donruetai Thalapphet donruetaithalapphet@gmail.com Piyathida Wongkham piyathida10012002@gmail.com Warissara Wongkham warissarawongkham@gmail.com Apinun Limmongkon apinunl@nu.ac.th Suchada Phimsen suchadaph@nu.ac.th

<p>Cholangiocarcinoma (CCA) is a highly aggressive malignancy with poor prognosis, partly because of late-stage diagnosis, therapeutic resistance, and metastatic progression. This study investigated the anticancer and anti-migratory, and anti-invasive effects of peanut hairy root culture crude extract (PCE), a source of prenylated stilbenoids including trans-arachidin-1 and trans-arachidin-3. The effects of PCE on cell viability were initially screened in KKU-213B, A549, MCF-7, and KB cancer cells. PCE reduced cell viability in a concentration-dependent manner, with KKU-213B cells showing the greatest sensitivity among the tested cell lines. The effects of PCE on cell viability were subsequently evaluated in a panel of CCA cell lines comprising KKU-213A, KKU-213B, KKU-055, and the highly metastatic KKU-213AL5 subline. KKU-213AL5 cells exhibited the greatest sensitivity and were therefore selected for further investigation. At non-cytotoxic concentrations, PCE significantly suppressed KKU-213AL5 cell migration and invasion, as determined by wound-healing and Matrigel-coated Transwell assays, respectively. Gelatin zymography showed that PCE did not significantly alter MMP-2 or MMP-9 activity. Collectively, these findings demonstrate that PCE inhibits the cell viability, migration, and invasion of highly metastatic CCA cells, supporting further investigation of its active constituents and underlying molecular mechanism.</p>

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