https://li01.tci-thaijo.org/index.php/JBAP <p><span style="font-size: medium;"><strong>Journal of Basic and Applied Pharmacology</strong> <strong>(J Basic App Pharmacol) </strong>(former title: Thai Journal of Pharmacology) is a peer-reviewed journal publishing original research articles, reviews, case reports, letters to editors and commentaries on pharmacology and related fields, i.e. pharmacodynamics, pharmacokinetics, pharmacotherapeutics, toxicology, clinical pharmacology, molecular pharmacology, pharmacogenetics/pharmacogenomics, comparative pharmacology, safety pharmacology, systems pharmacology, pharmacoepidemiology and ethnopharmacology. The research article and review of all fields must be peer-reviewed by at least three reviewers. Thai Journal of Pharmacology has been abstracted and indexed by <strong>Thai Journal Citation Index (TCI - Tier 1)</strong> and <strong>ASEAN Citation Index (ACI)</strong>. The indexing in the TCI and ACI is continued with the <strong>Journal of Basic and Applied Pharmacology.</strong></span><span style="font-size: medium;"><strong><br /></strong></span></p> <p> </p> <p><span style="font-size: medium;"><strong>ISSN: 2774-0854 (Online)</strong></span></p> The Pharmacological and Therapeutic Society of Thailand en-US Journal of Basic and Applied Pharmacology 2774-0854 <p>Upon acceptance of an article, the&nbsp;Pharmacological and Therapeutic Society of Thailand will have exclusive right to publish and distribute the article in all forms and media and grant rights to others. Authors have rights to use and share their own published articles.</p> https://li01.tci-thaijo.org/index.php/JBAP/article/view/273004 <p>Cholangiocarcinoma (CCA) is a highly aggressive malignancy with poor prognosis, partly because of late-stage diagnosis, therapeutic resistance, and metastatic progression. This study investigated the anticancer and anti-migratory, and anti-invasive effects of peanut hairy root culture crude extract (PCE), a source of prenylated stilbenoids including trans-arachidin-1 and trans-arachidin-3. The effects of PCE on cell viability were initially screened in KKU-213B, A549, MCF-7, and KB cancer cells. PCE reduced cell viability in a concentration-dependent manner, with KKU-213B cells showing the greatest sensitivity among the tested cell lines. The effects of PCE on cell viability were subsequently evaluated in a panel of CCA cell lines comprising KKU-213A, KKU-213B, KKU-055, and the highly metastatic KKU-213AL5 subline. KKU-213AL5 cells exhibited the greatest sensitivity and were therefore selected for further investigation. At non-cytotoxic concentrations, PCE significantly suppressed KKU-213AL5 cell migration and invasion, as determined by wound-healing and Matrigel-coated Transwell assays, respectively. Gelatin zymography showed that PCE did not significantly alter MMP-2 or MMP-9 activity. Collectively, these findings demonstrate that PCE inhibits the cell viability, migration, and invasion of highly metastatic CCA cells, supporting further investigation of its active constituents and underlying molecular mechanism.</p> Donruetai Thalapphet Piyathida Wongkham Warissara Wongkham Apinun Limmongkon Suchada Phimsen Copyright (c) 2026 Journal of Basic and Applied Pharmacology https://creativecommons.org/licenses/by-nc-nd/4.0 2026-09-02 2026-09-02 6 2 O77 88