A Preliminary Study of Insulin-like Growth Factor 1 Receptor (IGF-1R) in Placental Malaria

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Sethawud Chaikitgosiyakul
Urai Chaisri
Parnpen Viriyavejakul
Sumate Ampawong
Gareth DH Turner
Emsri Pongponratn



Placental malaria continues to be a major health problem, causing low birthweight and maternal  anemia. This study quantified the histopathology of placental malaria by staining sections with hematoxylin & eosin (H&E) and investigating the expression of insulin-like growth factor 1 receptor (IGF-1R). Through immunohistochemical staining of one control and two placental malaria cases, and by examining histological slides, placental malaria parasitemia at delivery was found to be 5% and 15%, respectively. Malaria pigment deposition was remarkable. Inflammatory cell infiltration presented in one case only. IGF-1R staining in the control showed strong expression, while placental malaria presented weak expression. The result of this preliminary study shows a need for further investigations with more cases, to confirm that insulin-like growth factor (IGF) axis disturbance may represent one mechanism by which placental malaria could lead to restricted fetal growth.

Keywords: malaria, placenta, histopathology, IGF-1R

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