@article{Tangsucharit_Kukongviriyapan_Kukongviriyapan_Airarat_2013, title={Screening for Analgesic and Anti-inflammatory Activities of Extracts from Local Vegetables in Northeast Thailand}, volume={21}, url={https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/13687}, abstractNote={<h1><span style="text-decoration: underline;">Background</span>: Northeast region of Thailand is one of the rich source of vegetables, the favorite Thai food in daily diet. There are very few pharmacological studies in folk vegetables.</h1> <p><strong><span style="text-decoration: underline;">Objectives</span></strong><strong>:</strong> This study described screening tests for the analgesic and anti-inflammatory activities of 10 local vegetables inhabitated in the Northeast region of Thailand.<strong></strong></p> <p><strong><span style="text-decoration: underline;">Method</span></strong><strong>: </strong>Analgesic activity was assessed by writhing test and tail flick test. Anti-inflammatory activity was assessed by rat hind paw edema model.<strong></strong></p> <p><strong><span style="text-decoration: underline;">Results</span></strong><strong>:</strong> The water extract of vegetables at 1 g/kg administered orally in Swiss albino male mice was used to test for analgesic activity in the acetic acid-induced writhing test model. The extracts from <em>Coccinia grandis (L.) Voigt., Tiliacora triandra Diels., Barringtonia acutangula Gaerth., Brassica juncea (Linn.) Czern&Coss., Limnophila aromatica (Lomk) Merr., Piper samentosum Roxb. Ex. Hunter </em>and <em>Anethum graveolens Linn. </em>elicited significant inhibition of writhing reflex by 35-64% (p<0.05) when compared with diclofenac (72% inhibition) The four most potent extracts were further tested for anti-inflammatory activity. However, none of them possessed any anti-inflammatory effect in carragenan-induced rat paw edema assay. Nevertheless, the extracts from <em>Coccinia grandis (L.) Voigt. </em>and <em>Tiliacora triandra Diels. </em>showed weak analgesic activity in tail flick test.<strong></strong></p> <p><strong><span style="text-decoration: underline;">Conclusions</span></strong><strong>:</strong> It was concluded that the Northeast Thailand local vegetables such as <em>Coccinia grandis </em>and <em>Tiliacora triandra </em>show some analgesic property and none has anti-inflammatory action.</p>}, number={4}, journal={Srinagarind Medical Journal}, author={Tangsucharit, Panot and Kukongviriyapan, Veerapol and Kukongviriyapan, Upa and Airarat, Wanchai}, year={2013}, month={Nov.}, pages={305–310} }