TY - JOUR AU - Ratchawan, Pimpa AU - Trakulthong, Jindarat AU - Kangwantrakul, Wisut AU - Promdee, Limthong PY - 2013/10/31 Y2 - 2024/03/29 TI - Glycosylation index in type 2 diabetic patients with nephropathy JF - Srinagarind Medical Journal JA - SRIMEDJ VL - 25 IS - 4 SE - Original Articles DO - UR - https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/12934 SP - 280-286 AB - <p><strong> </strong></p> <p><strong><span style="text-decoration: underline;">Background and objective :</span></strong><strong> </strong>Glycosylation index is composed of glycosylation gap (GG), hemoglobin glycation index (HGI), fructosamine glycation index (FGI).  The indeces are index calculated based on blood glucose (BG), fructosamine (F), and glycated hemoglobin (HbA<sub>1C</sub>).  The purpose of this study was to compare these indices in type 2 diabetic patients (T2DM) with various  stages of nephropathy.</p> <p><strong><span style="text-decoration: underline;">Methods:</span></strong><strong> </strong> HbA<sub>1C</sub>, BG and F were obtained from 104 T2DM patients (37 males, 67 females) at a single clinical visit at Buddhachinnaratana Hospital, Pitsanulok.  The stages of nephropathy was divided into 3 groups according to albuminuria level; no nephropathy (n = 57), microalbuminuria (n = 29), and advanced nephropathy (n = 18).</p> <p><strong><span style="text-decoration: underline;">Results :</span></strong><strong> </strong>Mean±SD HbA<sub>1C</sub> = 7.9±1.7%, F = 279±69 mmol/L, BG = 7.0±1.9 mmol/L, GG = 0.0±2.37, HGI = -0.23±1.47, and FGI = -0.21±63 were found in all subjects.  Mean GG (0.55±0.8), HGI (0.70±1.5), and HbA<sub>1C</sub> (9.0±1.8%) in patients with advanced nephropathy was significantly different from those with no nephropathy and microalbuminuria (<em>P</em> &lt; 0.05),</p> <p><strong><span style="text-decoration: underline;">Conclusions :</span></strong><strong> </strong> Increasing levels of HbA<sub>1C</sub> indicate with worsening nephropathy in T2DM.</p> <p><strong><span style="text-decoration: underline;">Key words</span></strong>: Glycosylation index; type 2 diabetes mellitus; Microalbuminuria; Nephropathy</p> ER -