TY - JOUR AU - Boonnate, Piyanard AU - Pethlert, Supattra AU - Sharma, Amod AU - Hipkaeo, Wiphawi AU - Waraasawapati, Sakda AU - Prasongwattana, Vitoon AU - Cha'on, Ubon PY - 2013/11/27 Y2 - 2024/03/29 TI - The Effects of Monosodium Glutamate Consumption on Oral Glucose Tolerance Test (OGTT) in Rats JF - Srinagarind Medical Journal JA - SRIMEDJ VL - 28 IS - 4 SE - Proceeding DO - UR - https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/14892 SP - 276-278 AB - <p class="NoSpacing"><strong><span style="text-decoration: underline;"><span>Background and Objective</span></span></strong><span style="text-decoration: underline;"><span>:</span></span><span lang="TH"> </span><span>Monosodium glutamate (MSG) is a sodium salt of glutamic acid, widely used as a food additive both in household and food industry. An injection of MSG into newborn mice causes of several metabolic disorders such as obesity, non-alcoholic fatty liver disease and type 2 diabetes. We aimed to investigate the effect of MSG consumption on glucose regulation in adult rats.</span></p> <p class="NoSpacing"><strong><span style="text-decoration: underline;"><span>Methods:</span></span></strong><span> Twenty adult male Wistar rats were randomly divided into control and treatment groups. Both groups were fed<span> </span><em>ad libitum</em><span> </span>with a standard rat chow pellet and water, except the treatment group were received MSG (2 mg/g body weight/day) in drinking water for nine months. Oral glucose tolerance tests (OGTT) were investigated. </span><span>Water intake, food intake and body weight<strong><span> </span></strong><span>were also recorded.</span></span></p> <p class="NoSpacing"><strong><span style="text-decoration: underline;"><span>Results:</span></span></strong><strong><span> </span></strong><span>There were no significant differences in OGTT results between control and MSG-treated animals. MSG-treated rats had significantly higher water intake compared to controls. However there were no significant differences in food intake and body weight between control and MSG-treated animals.</span></p> <p class="NoSpacing"><strong><span style="text-decoration: underline;"><span>Conclusion: </span></span></strong><span>The results revealed that daily MSG consumption with the dose of 2 mg/g body weight /day for nine months had no effect on OGTT, an index of glucose regulation, in adult rats. </span></p> <p class="NoSpacing"><strong><span style="text-decoration: underline;"><span>Key words: </span></span></strong><span> monosodium glutamate, oral glucose tolerance test, islets of Langerhans</span></p> ER -