TY - JOUR AU - Nirunsiriphol, Sawanee PY - 2021/01/18 Y2 - 2024/03/29 TI - Comparison of Acute Radiation Dermatitis between Hypofractionated and Conventional Radiotherapy in Postmastectomy Breast Cancer JF - Srinagarind Medical Journal JA - SRIMEDJ VL - 36 IS - 1 SE - Original Articles DO - UR - https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/248653 SP - 15-23 AB - <p><strong><u>Objective:</u></strong> To compare the acute radiation dermatitis between hypofractionated radiotherapy (HFRT) and conventional radiotherapy (CRT) in postmastectomy breast cancer.</p><p><strong><u>Methods:</u></strong> This study was the experimental research design (randomized controlled trial). Seventy six patients underwent a mastectomy and divided into two groups with &nbsp;38 cases in group I used HFRT regimen 42.56 Gy in 16 fractions over three weeks and 38 cases in group 2 used CRT regimen 50 Gy in 25 fractions over five weeks. The study was performed at Division of Radiation Oncology, Roi Et Hospital, from January 1, 2019, to April 30, 2020. All cases were categorized in different grading of acute radiation dermatitis by Radiation Oncologist at Week 1,2,3 during radiation and 1 month, 3 months post-radiation. The statistical analyzed were used descriptive statistics and Z-test. The statistical significance was set at p&lt;0.05.</p><p><strong><u>Results:</u></strong><strong>&nbsp; </strong>There was no significant difference of acute radiation dermatitis in CRT and HFRT. We found that acute radiation dermatitis grade 1 at week 1,2and 3 during radiotherapy of CRT vs HFRT was 5.26% vs.7.89% (p=0.644), 28.95% vs. 18.42% (p=0.280), 50% vs. 28.95% (p=0.085), respectively. Acute radiation dermatitis grade 1 of the first-month postmastectomy radiation was 15.79% vs. 10.53% (p=0.301) in patients treated with CRT vs. HFRT. Dermatitis grade 1 was the most common grade for acute radiation dermatitis. Few patients in this study developed grade 2 or more skin toxicities.</p><p><strong><u>Conclusion:</u></strong> This study revealed that the treatment outcome of acute radiation dermatitis between HFRT (42.56 Gy in 16 fractions) and CRT (50Gy in 25 fractions) in postmastectomy breast cancer was not different. Hypofractionated radiotherapy is shortening treatment time, reduces cost-saving, and more convenient.</p> ER -