TY - JOUR AU - Pothipan, Phattarin AU - Bunthot, Supawadee AU - Wongkham, Sopit AU - Vaeteewoottacharn, Kulthida PY - 2016/10/05 Y2 - 2024/03/29 TI - Role of CD47 on Progression of Cholangiocarcinoma JF - Srinagarind Medical Journal JA - SRIMEDJ VL - 31 IS - 5 SE - Abstract of Interesting DO - UR - https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/68231 SP - 65 AB - <p style="margin: 0cm 0cm 0pt; line-height: 150%;"><span style="font-size: medium;"><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">Background and Objective</span></span></strong><strong><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">:</span></strong><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt; mso-ansi-language: EN-US;">Cholangiocarcinoma (CCA) is an aggressive bile duct cancer. The involvements of chronic inflammation and increased tumor-associated macrophage (TAM) have been previously reported. </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">CD47 is widely expressed on cell surface of many cells in the body. It plays a role in self-recognition and inhibiting phagocytosis, so-called </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">β€œ</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">don</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">’</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">t eat me” signal</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">. </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">CD47 is overexpressed in various cancer</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">. </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">However, the role of CD47 in CCA is still unclear</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">.</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB"> Thus, the aim of this study is to investigate the expression of CD47 in CCA tissues compared with other liver diseases</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">.</span></span></p><p style="margin: 0cm 0cm 0pt; line-height: 150%;"><span style="font-size: medium;"><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">Methods</span></span></strong><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">:</span></span></strong><strong></strong><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">CD47 expression in 98 paraffin embedded tissues </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt; mso-ansi-language: EN-US;">that consist of CCA (n=70), hepatocellular carcinoma (HCC) (n=22) and other non-tumor liver diseases (n=6), such as hemangioma, and cirrhosis, </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">were investigated by immunohistochemistry method</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">. </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">The </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt; mso-ansi-language: EN-US;">Clinico<span lang="TH">-</span>pathological correlation was investigated<span lang="TH">.</span></span></span></p><p style="margin: 0cm 0cm 0pt; line-height: 150%;"><span style="font-size: medium;"><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">Results</span></span></strong><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">:</span></span></strong><strong></strong><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt; mso-ansi-language: EN-US;">The results showed that CD47 was expressed in 79% of CCA tissues, </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">41% of HCC, and 50% of other diseases. However, there were intensely expressed in CCA tissues while weak expressions were detected in other liver diseases. Moreover, the </span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt; mso-ansi-language: EN-US;">expression of CD47 was associated with shorter survival of CCA patients.</span></span></p><p style="margin: 0cm 0cm 0pt; line-height: 150%;"><span style="font-size: medium;"><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">Conclusion</span></span></strong><strong><span style="text-decoration: underline;"><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">:</span></span></strong><strong></strong><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB">CD47 is highly expressed in CCA when compared to other liver disease and the level of expression was correlated with the poor clinical outcome of the patient. Therefore, CD47 might play the <a name="_GoBack"></a>role in host immune invasion of CCA</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="TH">.</span><span style="line-height: 150%; font-family: 'Tahoma','sans-serif'; mso-bidi-font-size: 11.0pt;" lang="EN-GB"> Further investigation needs to be elucidated.</span></span></p> ER -