Srinagarind Medical Journal <p>Frequency : in every&nbsp;two months; on February, April, June, August, October&nbsp;and December. Policy is to encourage distribution of scientific information in medical and health sciences. It publishes seven types of article; medical innovation, original article, case report, review article, conference, symposium and letter to editor.</p> Faculty of Medical, Khon Kaen University en-US Srinagarind Medical Journal 0857-3123 Incidence and Predictors of Residual Disease in Women with High-grade Squamous Intraepithelial Lesion (HSIL) and Positive Margins after Cervical Loop Electrosurgical Excision <p><strong><u>Background and Objective:</u></strong> Women who have high-grade squamous intraepithelial lesion (HSIL) and positive margins after an initial cervical loop electrosurgical excision procedure (LEEP) carry a risk of invasive cervical carcinoma if left untreated. This study aimed to find factors predicting residual disease in women with histologic HSIL and positive margins after LEEP.</p> <p><strong><u>Methods:</u></strong> This retrospective cohort study was undertaken among women with histologic HSIL who had positive surgical margins following LEEP at Lamphun Hospital between January 2014 and March 2020. Factors predicting residual lesion were assessed by univariate and multivariate logistic regression analysis.</p> <p><strong><u>Results:</u></strong> One hundred and thirteen women were included, residual disease was found in 56 women (49.5%). Multivariate analysis showed that only age <u>&gt;</u>35 years (AOR = 10.8; 95%CI 1.1-109.8, p = 0.045) and a large lesion on LEEP specimen (3-4 quadrants) (AOR = 9.5; 95%CI 3.4-26.2, p &lt;0.001) were significantly independent factors associated with residual disease.</p> <p><strong><u>Conclusions:</u></strong> Age <u>&gt;</u>35 years and large lesion are the significant independent predictors for residual disease in women who had HSIL with positive margins after LEEP.</p> Chalita Kingnate Copyright (c) 2020-09-08 2020-09-08 35 5 515 522 Factors Associated with Pulmonary Tuberculosis among Diabetic Patients in Ban Fang Hospital, Khon Kaen Province <p><strong><u>Background and Objective:</u></strong><strong> &nbsp;</strong>Poor control diabetic patients are at risk of various infections including tuberculosis (TB). This study aimed at studying factors associated with pulmonary tuberculosis infection in diabetic patients</p> <p><strong><u>Method:</u></strong> An unmatched case-control study was conducted among type 2 diabetes mellitus (T2DM) patients in Ban Fang hospital, Khon Kaem from October 1<sup>st</sup>, 2012 to April 30<sup>th</sup>, 2019. The study group included all T2DM patients who were diagnosed with pulmonary TB, where as the control group were T2DM patients without pulmonary TB diagnosis. Subjects in control group were randomly selected into a ratio 1:2 of case per control. Data collections were performed by reviewing medical records of the hospital database. Data were analyzed using descriptive and analytic approaches such as frequency, percentage, Pearson Chi-square test, Independent-Samples T-test, Odds ratio and multiple logistic regression.</p> <p><strong><u>Results:</u></strong> A total of 210 subjects were selected comprising 68 cases of study groupand 142 case of control group. The factors which were significantly related to pulmonary TB among diabetic patients included:&nbsp; FBS&nbsp;≥180 mg/dl (Adjusted OR = 5.63, 95% CI: 2.61-12.16); BMI&lt;23 kg/m<sup>2</sup> (Adjusted OR = 4.86, 95% CI: 2.18-10.84); receiving insulin injection (Adjusted OR = 0.31, 95% CI: 0.13-0.74) and male (Adjusted OR = 2.28, 95% CI: 1.06-4.88).</p> <p><strong><u>Conclusion:</u> </strong>T2DM patients with high FBS, normal or low BMI and male gender were at high risk of pulmonary TB infection, while patients with history of taking insulin injection were at lower risk.</p> Paramee Trakulkajornsak Pattapong Kessomboon Copyright (c) 2020-09-08 2020-09-08 35 5 523 530 The Validity of Pre- and Post-Anterior Cruciate Ligament Reconstruction Surgery Manual of Srinagarind Hospital <p><strong><u>Background and objectives:</u></strong>&nbsp;The anterior cruciate ligament reconstruction (ACLR) patient care effects on patient recovery. Nowadays, there are several guidelines for ACLR patients. This study evaluated the validity of the ACLR manual of Srinagarind Hospital; hence, the care is in the same direction.&nbsp;</p> <p><strong><u>Methods:</u></strong>&nbsp;&nbsp;The validity and suitability of knowledge, language and pictures were evaluated by the professionals and medical personnels. The index of item objective congruence (IOC) of each topics was reportes. The IOC ≥ 0.8 meant that data was according to the objective. The manual was adjusted and analyzed again until all IOC was ≥ 0.8.</p> <p><strong><u>Results:</u></strong>&nbsp;&nbsp;The validity that evaluated by eight professionals, the IOC of the picture in ACL knowledge, preoperative care, second phase of rehabilitation, and knowledge in fifth phase of rehabilitation were equal to 0.375, 0.75, 0.75, and 0.75 respectively. The suitability that evaluated by 30 medical personnels, the IOC of the picture in the ACL knowledge section, was equal to 0.367. The IOC of all sections after adjusting was ≥ 0.8.</p> <p><strong><u>Conclusion:</u></strong>&nbsp;The ACLR patient care manual of Srinagarind Hospital was accurate and suitable for ACLR patients.</p> Punyawat Apiwatanakul Pajeemas Kittipanya-ngam Thavatchai Suvarnnato Artit Boonrod Sermsak Sumanont Copyright (c) 2020-09-08 2020-09-08 35 5 531 536 A Comparison Study of Walking Ability Using Thera-Band Wrapping at Knee Level and Hip Level in Stroke Patients <p><strong><u>Background and Objective:</u></strong> Rehabilitation for walking after stroke is crucial. Thera-Band can be an option for the gait rehabilitation in stroke patients with foot drop. The aim of this study was to examine the effect of Thera-Band wrapping at knee level and to compare the effect of knee and hip level wrapping on walking ability.</p> <p><strong><u>Methods:</u></strong> A randomized crossover trial was done in ten stroke patients.&nbsp; Patients were assessed by the Wisconsin Gait Scale (WGS) and the 10 meter walk test (10MWT) at baseline. Patients were then randomized to walk with Thera-Band wrapping at knee and hip levels. WGS and 10MWT were assessed for each wrapping level.</p> <p><strong><u>Results:</u></strong> Wrapping at knee level decreased WGS from 23.5 to 20.4 (p = 0.016), increased comfortable gait speed from 0.44 to 0.57 m/s (p = 0.007) and fast gait speed from 0.70 to 0.76 m/s (p = 0.017). Patients walking with wrapping at knee level had higher fast gait speed compared to wrapping at hip level (0.76 vs 0.73, p = 0.047). No difference was found in WGS and comfortable gait speed.</p> <p><strong><u>Conclusions:</u></strong> The use of Thera-Band wrapping at both hip and knee levels improved walking ability and gait speed. Thera-Band at knee level led to higher fast gait speed compared to hip level. &nbsp;</p> Supreeya Rachashiha Jittima Saengsuwan Copyright (c) 2020-09-08 2020-09-08 35 5 537 544 The Relationship of Lumbar Dysfunction and Range of Motion Limitation <p><strong><u>Background and objectives</u></strong><strong>:</strong> Low back pain is a health problem affecting daily living in terms of pain, movement and functional limitations. Lumbar dysfunction is commonly found and diagnosed by physical therapists. However, the relationships of lumbar dysfunction and related factors are not yet established. This study therefore aimed to investigate the relationships between the diagnosis of lumbar dysfunction and range of motion limitation, and posture.</p> <p><strong><u>Methods</u></strong><strong>:</strong> Study design and setting: The data of low back pain patients were obtained from medical records of Physical Therapy Center, Mahidol University, 252 cases totally, by which 131 cases were diagnosed as lumbar dysfunction and 121 cases diagnosed as other pathologies. The relationships between lumbar dysfunction and range of motion, posture were investigated by chi-square test and the characteristics of subjects were investigated by independent t-test.</p> <p><strong><u>Results</u></strong><strong>:</strong> Age, weight, and body mass index (BMI) were not significantly different between the two groups. Lumbar dysfunction group was correlated with range of motion limitation in all directions especially lumbar flexion and lumbar extension (p = 0.002, 0.006), but lumbar dysfunction group was not correlated with flat back posture</p> <p><strong><u>Conclusion</u>:</strong> Lumbar dysfunction had a relationship with range of motion limitation in all directions. Therefore, physical therapists should emphasize on physical examination and interventions regarding to range of motion for holistic approach.</p> Dedchawin Laisirirungrai Siriwan Yotsungnoen Worawan Ekabutr Prasert Sakulsriprasert Copyright (c) 2020-09-08 2020-09-08 35 5 545 551 Accuracy of Magnetic Resonance Imaging in Diagnosis of Morbidly Adherent Placenta <p><strong><u>Background and </u></strong><strong><u>Objective:</u></strong> To determine the sensitivity and specificity of MRI findings for detecting of <u>morbidly</u> adherent placenta<strong>.</strong></p> <p><strong><u>Methods:</u></strong> A retrospective review of the patients who underwent pelvic MRI during pregnancy between January 2004 and June 2014. Thirty-one image sets that met the following inclusion criteria were enrolled in the study. MR <u>imaging</u> findings included uterine bulging, intraplacental hemorrhage, placenta heterogeneity, intraplacental dark bands, present of myometrium plane were reviewed by two investigators blinded to pregnancy outcome.</p> <p><strong><u>Results:</u></strong> In thirty-one image sets of pelvic MRI in the pregnant patients. Sensitivity, specificity, PPV, NPV and kappa value of MRI features had calculated: uterine bulging (90.9%, 75%, 66.7%, 93.8% and 0.74 respectively); intraplacental hemorrhage (81.8%, 89.5%, 81.8%, 89.5% and 0.78); placental heterogeneity (100%, 15%, 39.3%, 100% and 0.34); intraplacental dark bands (100%, 55%, 55%, 100% and 0.49); partial/absent myometrium under placenta (100%, 80%, 73.3%, 100% and 0.83), respectively.Accuracy of MRI to diagnosed <u>morbidly</u> adherent placenta was 83.8% (95% CI 66.2%-94.5%) with moderate interobserver agreement (kappa value 0.58).</p> <p><strong><u>Conclusion:</u></strong> Uterine bulging, intraplacental hemorrhage and partial/absent myometrium plane may be the keys criteria to diagnosis on pelvic MRI. Placental homogeneity and absent intraplacental dark band on T2WI may be exclusive criteria.</p> Chalida Aphinives Thaiwat Tatsanawiwat Jiraporn Srinakarin Ratana Komwilaisak Pilaiwan Kleebkaow Copyright (c) 2020-09-08 2020-09-08 35 5 552 560 Complications of Liver Transplantation with Successful Treatment by Interventional Radiology Techniques <p><strong><u>Background and Objective:</u></strong> Liver transplantation is a treatment option for end-stage liver disease and acute liver failure. Early detection and treatment of postoperative complications have increased survival rates after liver transplantation. The objective of this study was to evaluate efficacy of the interventional radiology procedures in treatment of liver transplant complications.</p> <p><strong><u>Material and methods:</u></strong> This retrospective study included 13 patients with post liver transplantation related complications, which were treated with interventional radiology procedures from July 2013 to October 2018. Demographic data, indications for liver transplantation, type of liver transplantation, liver transplantation related complications, onset of complications, interventional radiology procedures and result of treatment were collected.</p> <p><strong><u>Results:</u></strong> Between July 2013 to October 2018, 13 patients undergoing 27 procedures were identified, including venoplasty for inferior vena cava and portal vein stenosis (n=3), angioplasty and stent placement without/with thrombolysis for hepatic artery stenosis and hepatic artery thrombosis (n=3), percutaneous transhepatic biliary drainage related procedures (insertion, exchange, and irrigation) for biliary stricture (n=9) and percutaneous drainage related procedures (insertion and exchange) for intraabdominal collections (n=12). Technical and clinical success rates were 100% and 96.3%, respectively.</p> <p><strong><u>Conclusion:</u></strong> Interventional radiology procedures have an important role in the management of postoperative complications of liver transplantation under non-operative and minimally invasive techniques with high technical and clinical success rates.</p> Jitraporn Wongwiwatchai Virin Bejrachandra Vivian Klungboonkrong Anucha Ahooja Arunnit Boonrod Copyright (c) 2020-09-08 2020-09-08 35 5 561 567 Clinical Outcome After Total Laryngectomy in Laryngeal and Hypopharyngeal Carcinoma <p><strong><u>Background and objective:</u></strong> Total laryngectomy has the major role in laryngeal and hypopharyngeal cancer treatment. The most common post-operative complication was pharyngocutaneous fistula particularly the patients who undergoing total laryngectomy after previous radiotherapy. This study aimed to evaluate the incidence of pharyngocutaneous fistula and also the overall survival after surgery.</p> <p><strong><u>Method:</u></strong> This is the retrospective study of patients who underwent total laryngectomy or total laryngopharyngectomy between 2014 and 2018 at National Cancer Institute, Thailand.</p> <p><strong><u>Results</u></strong><strong><u>:</u></strong> &nbsp;&nbsp;&nbsp;&nbsp;Forty-two male patients were included in the study. The primary total laryngectomy accounted for 66.7% of the laryngectomy procedures. Moreover, there was no patient experienced post-operative pharyngocutaneous fistula. In the follow-up period, there were 11 patients (26.2%) had recurrent disease.The most common pattern of recurrent was lung metastasis.The patients who underwent primary surgery had 3-year DFS, 5-years DFS, 3-year OS and 5-year OS as 79.4%, 79.4%, 77.3% and 65.6%, respectively. While the salvage surgery group had lesser surival outcome. This group&nbsp; had&nbsp; 3-year DFS , 5-years DFS , &nbsp;3-year OS and&nbsp; 5-year OS &nbsp;about 46.5% , 42.3% , 62.6% and&nbsp; 59.7%&nbsp; ,respectively. Nonetheless,there was statistically significant in DFS ( log rank test, p&lt; 0.05) between both groups but not&nbsp; in OS ( log rank test, p=0.66). Perineural invasion and extranodal extension were the significant negative impact factor in DFS.</p> <p><strong><u>Conclusion:</u></strong>&nbsp;&nbsp; Selecting the patients for appropriate surgical candidates together with repairing the neopharynx with zipper technique or PMM flap resulted no pharyngocutaneous fistula incidence in this study. Moreover, the post-operative radiotherapy or post-operative chemoradiation after surgery encouraged&nbsp; the survival outcome in primary surgery group in this study.</p> Ekapob Sangariyavanich Copyright (c) 2020-09-08 2020-09-08 35 5 568 575 Outcomes of Pharmacist Intervention in Schizophrenic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials <p><strong><u>Background and Objective</u></strong><strong>: </strong>There are many pharmacy interventions for schizophrenic patients. This study aimed to systematically review the literatures and conduct a meta-analysis on the outcomes of pharmacist intervention in schizophrenia patients.</p> <p><strong><u>Methods</u></strong><strong>: </strong>Research articles from international electronic databases (PubMed, Scopus, Cochrane CENTRAL, Science Direct, PSyINFO) and Thai electronic databases were searched and collected. The randomized controlled trials that investigated the outcomes of medication adherence, clinical outcomes and quality of life were selected. The analysis method depended on the heterogeneity. The random-effect model was used when the data was heterogeneity, whereas the fix-effect model was used when the data was not heterogeneity. The pool estimation was analyzed to report the standard mean difference (SMD) and benefit ratio, and the proportion of patients with improvement of outcome (as relative risk).</p> <p><strong><u>Results</u></strong><strong>: </strong>There were nine studies with a total of 673 schizophrenia patients met the inclusion criteria. Results of meta-analysis showed that the pharmacist intervention statistically significant affected on the medication adherence. The mean score of medication adherence of patients in the pharmacist intervention group were more than the control group (SMD=0.60, 95% CI 0.41, 0.79) and the pooled relative risk for medication adherence was 1.13 (95% CI 1.07, 1.19).</p> <p><strong><u>Conclusion</u></strong>: pharmacist intervention improved the medical adherence of schizophrenic patients.</p> Nathapol Samprasit Waranee Bunchuailua Nattiya Kapol Copyright (c) 2020-09-08 2020-09-08 35 5 576 583 Depression and Medication Adherence in Continuous Ambulatory Peritoneal Dialysis Patients <p><strong><u>Background and Objectives</u></strong><strong>:</strong> The number of continuous ambulatory peritoneal dialysis (CAPD) patients had been trending upwards every year. Meanwhile, many people were suffering from depression. This study was conducted to observe the prevalence of depression and to analyze the relationship between depression and medication adherence among CAPD patients.</p> <p><strong><u>Methods</u></strong><strong>:</strong> This cross-sectional descriptive study was performed in 115 CAPD patients at HRH Princess Maha Chakri Sirindhorn medical center.</p> <p><strong><u>Results</u></strong><strong>:</strong> The prevalence of depression was 40%. The factors affecting depression were education level, duration (years) of having chronic kidney disease, duration (years) of undergoing CAPD and serum albumin level. There was a relationship between depression and medication adherence in CAPD patients (p = 0.034). Those patients with depression had lower level of medication adherence than those without depression. Moreover, depression tended to be associated with those who undergoing CAPD for the first 5 years.</p> <p><strong><u>Conclusion</u></strong><strong>:</strong> Forty percent of CAPD patients at HRH Princess Maha Chakri Sirindhorn medical center had depression. Depression was associated with lower medication adherence. Therefore, the screening for depression should be considered in patients undergoing CAPD particularly in the first 5 years.</p> Chanon Jarupaktranonth Kantapat Puanglai Siribha Changsirikulchai Jirayut ๋Janma Wannakon Chuemongkon Copyright (c) 2020-09-08 2020-09-08 35 5 584 590 The Effects of Orientation and Mobility Training on Functional Abilities and Self-Esteem of Persons with Visual Impairment <p><strong><u>Background and Objective:</u></strong> In Thailand, the orientation and mobility (O&amp;M) training for persons with visual impairment (VI) has been promoted to increase their independent living. However, studies about the effects of O&amp;M training were limited. This study aimed to evaluate changes in functional abilities and self-esteem of persons with VI after participating in an O&amp;M training course.</p> <p><strong><u>Methods:</u></strong> Participants were 40 persons with VI who received an 80-hour O&amp;M training course of Kuchinarai Crown Prince Hospital, Kalasin Province. Their functional abilities were assessed at baseline, after finishing the training (week 4) and at the follow-up period (week 12) by using an assessment form designed by the investigators. Additionally, at baseline and week 12, the participants were requested to answer the Rosenberg Self-esteem Scale-Thai version. Data were analyzed by using descriptive statistics, repeated measures ANOVA and paired t-test.</p> <p><strong><u>Results:</u></strong> After the O&amp;M training, the participants significantly increased their functional abilities and self-esteem (<em>p</em>&lt;0.001).</p> <p><strong><u>Conclusions:</u></strong> The 80-hour O&amp;M training could improve functional abilities and self-esteem of persons with VI. These findings should be useful for designing O&amp;M training curricula which are relevant to characteristics and contexts of persons with VI in other communities.</p> Pawinee Layothee Nomjit Nualnetr Copyright (c) 2020-09-08 2020-09-08 35 5 591 597 Cratoxylum formosum Extract Alleviates Left Ventricular Hypertrophy in Nitric Oxide-Deficient Rats <p><strong><u>Background and Objectives</u></strong>: <em>Cratoxylum formosum</em> (CF), Tiew Khao, is a local plant that exerts antioxidant and anti-inflammatory effects. This study aimed to investigate the effects of CF extract on left ventricular (LV) hypertrophy and oxidative stress in nitric oxide-deficient rats.</p> <p><strong><u>Methods</u></strong>: Male Sprague-Dawley rats were divided into 3 groups including control group received normal drinking water, N<sup>ω</sup>-nitro L-arginine methyl ester hydrochloride (L-NAME) group received L-NAME (40 mg/kg/day) for five weeks and L-NAME group treated with CF extract (500 mg/kg/day) for the last two weeks. At the end of experiment, heart weight, LV wall thickness and cross-sectional area, vascular superoxide production and plasma malondialdehyde were measured.</p> <p><strong><u>Results</u></strong>: Rats received L-NAME showed LV hypertrophy and increases in oxidative stress markers (p&lt;0.05). &nbsp;Treatment with CF extract significantly alleviated LV hypertrophy associated with reducing oxidative stress markers in L-NAME treated rats.</p> <p><strong><u>Conclusion</u></strong>: CF extract alleviated LV hypertrophy in L-NAME rats which might be related with its antioxidant properties.</p> Prapassorn Potue Putcharawipa Maneesai Upa Kukongviriyapan Parichat Prachaney Poungrat Pakdeechote Copyright (c) 2020-09-08 2020-09-08 35 5 598 602 Effect of Exposure to Low-Level Toluene on Learning and Memory in Mice <p><strong><u>Background and Objective:</u></strong> Focusing on the study of the effects of exposure toluene on brain functions related to learning and memory. To analyze the level of exposure toluene that affect neurological behavior.</p> <p><strong><u>Methods:</u></strong> &nbsp;Experimental mice were exposed to different levels of toluene 5 days per week for 4 weeks continuously. The behavior and duration of the swimming mice in the zone that used to have an underwater platform were testing prior and after exposure to toluene by the Morris Water Maze Test. The statistical differences were analyzed by the Paired sample t-test, One-way ANOVA, and Repeated- Measures ANOVA</p> <p><strong><u>Result:</u></strong> Experimental mice that exposed to toluene concentration of 50, 100 and 150 ppm.&nbsp; There was a statistically significant difference in learning with control mice at the level of 0.01. The mean swimming duration of the post-control mice was statistically significant at the level of 0.01. Three groups of experimental mice showed no significant difference in the meantime. When analyzing the differences between the groups, it was found that the mean duration of the control and experimental group mice. After exposed to toluene with different tendencies (p &lt;0.01)</p> <p><strong><u>Conclusion</u></strong><u>:</u> Continuous exposure to low concentrations of toluene affects learning and memory in experimental mice. Must be studied clearly in humans. In order to see the health effects of those who need to work And will lead to the determination of appropriate preventive measures.</p> <p>&nbsp;</p> Pichai Kantachai Sirinya Laten Narakorn Sareelae Kanlaya Munluan Wittaya Byagghantara Kanit Sripankaew Copyright (c) 2020-09-08 2020-09-08 35 5 603 608 Attitudes towards the Use of Auxiliary Labels among Outpatients in a Community Hospital and 4 Health Promoting Hospitals <p><strong><u>Background and objectives:</u></strong> Rational Drug Use (RDU) project has been established to solve drug-related problems especially insufficient patients’ knowledge on medication use. Auxiliary labels has been launched to support all patients to get more access in drug labels and increase knowledge of their medications. Therefore, this study aimed to survey attitudes of outpatients towards the use of auxiliary labels and to assess factors related to the patients’ attitudes.</p> <p><strong><u>Method:</u></strong> This cross-sectional study was conducted in a community hospital and four health promoting hospitals under the ministry of public health, Nakhon Ratchasima province. The study enrolled patients at the age of 18 and over who had received at least one out of ten drugs including allopurinol, amlodipine, colchicine, domperidone, enalapril, glipizide, ibuprofen, paracetamol, paracetamol mixed with orphenadrine, and simvastatin, and those had at least one month of drug use history. The sample was selected by purposive sampling in the total number of 1,000 respondents (100 for each drug). All patients received a questionnaire about the attitudes towards using auxiliary labels consisting of 14 items. Data was assessed using 5-point Likert scales and interpreted into 3 levels of the patients’ attitudes towards using auxiliary labels as poor, fair and good.</p> <p><strong><u>Results:</u></strong> Of the total 1000 patients, 51.8% were females with an average age of 55.61 ± 12.86 years old. The patients expressed their attitudes towards use of auxiliary labels at a good level 35.5% (mean ± SD = 56.58 ± 3.40) and a fair level 64.5% (mean ± SD = 43.34 ± 3.53). The patients strongly agreed with the top 3 following statements about auxiliary labels: "Auxiliary labels are reliable information sources" (32.2%), "If you have any questions about drug use, auxiliary labels will be the first option that you choose to use" (30.3%), and "Auxiliary labels help you remember the names of the drugs you received" (26.9%). Patients strongly disagreed with the top 3 following statements about auxiliary labels: "There is no need to have an auxiliary label for every drug" (32.6%), "Auxiliary labels make you feel uncomfortable to inform healthcare professionals when having side effects” (28.2%), and "When reading auxiliary labels, you want to stop using the medicines" (26.4%). Regarding the multivariate analysis, the independent factors related to better attitudes towards using auxiliary labels including age (OR 0.450, p=0.005), careers (OR 0.474, p=0.005), higher income (OR 6.187, p=0.002) and number of drugs currently used (OR 0.177, p=0.002).</p> <p><strong><u>Conclusion:</u></strong> Patients had good attitudes towards auxiliary labels and they were aware of the importance of auxiliary labels. Therefore, strategies to increase patients’ recognition about the importance of auxiliary labels should be promoted. Also, auxiliary labels in all drugs prescribed should be provided to patients to increase knowledge of their medications.</p> Suyapat Konchoho Narumol Jarernsiripornkul Copyright (c) 2020-09-08 2020-09-08 35 5 609 616 The Effectiveness of Desferrioxamine Administration by Retained IV Catheter into Subcutaneous towards Pain and Satisfaction in Thalassemic Patients <p><strong><u>Background and objective</u></strong><strong>:</strong> <strong>&nbsp;</strong>Desferrioxamine injection is a method of treatment for iron overloaded thalassemic patients, recommended by subcutaneous injection. Currently using retained Butterfly needle into subcutaneous, causing pain and dissatisfaction, therefore it was changed to retained&nbsp; IV Catheter into subcutaneous.The purpose of this research was to evaluate the effectiveness of Desferrioxamine administration by Retained IV Catheter into Subcutaneous towards pain and Satisfaction in Thalassemic Patients.</p> <p><strong><u>Methods</u></strong> : &nbsp;This investigation was a Quasi-experimental research, one group pretest – posttest design.Selected by purposive sampling focused on 30 inclusion criteria patients.The research tool were 1) A pain assessment 2) A satisfaction assessment.Data was analyzed by using frequency, percentage,means,standard deviation,and Paired t-test.</p> <p><strong><u>Results</u></strong> : The results showed that using Desferrioxamine injection by retained IV-Catheter into subcutaneous, patients had overall pain at the level of no pain (0.40±0.81). While retained butterfly needle into subcutaneous, the patients had moderate pain (5.40±1.19). Comparison the pain of both injection methods, it was found that there were statistically significant differences (p&lt;0.001).&nbsp; Whereas the satisfaction of Desferrioxamine injection by retained IV-Catheter into subcutaneous is the highest level (4.40±0.50), while the butterfly needle was at a moderate level (2.87±0.35) and found that satisfaction with both methods has statistically significant differences (p&lt;0.001).</p> <p><strong><u>Conclusion </u></strong><strong>: </strong>An iron chelotor, Desferrioxamine injection by retained IV-Catheter into subcutaneous, thalassemic patients had less pain and more satisfaction than retained butterfly needle into subcutaneous.</p> Ruenrudee Kaennak Jitpinan Srijakkot Arunee Jetsrisuparp Kannika Chathum Copyright (c) 2020-09-08 2020-09-08 35 5 617 623 Unit Cost Analysis of Sterile Surgical Drape Pack Production for the Operating Rooms at Srinagarind Hospital, Faculty of Medicine, Khon Kaen University. <p><strong><u>Background and Objective:</u></strong> Healthcare institutions can improve administration through effective cost</p> <p>management. This study aimed to evaluate the production cost of in-house sterile surgical drape packs at Srinagarind hospital, Faculty of Medicine, Khon Kaen university, and compare to the prices of externally procured counterparts.</p> <p><strong><u>Methods</u></strong>: The descriptive study was conducted as follows: 1) analyzing workflow of hospital units related to the production of sterile surgical packs; 2) determining the components of economic and accounting costs of in-house surgical packs; 3) calculating the direct cost of surgical pack production based on labors, supplies, infrastructure, and maintenance; and 4) determining the cost per unit for each type of the packs, and for each type of procedure.</p> <p><strong><u>Results:</u></strong> Among 27 types of surgical drape packs, unit cost ranged from 26.81 to 192.11 baht, with the average of 100.31 baht. The results showed that the cost of in-house sterile surgical drape packs varied from 405 to 909 baht, averaging 549 baht per procedure, while the cost of an outsourced drape pack averaged 2,191 baht, with prices falling between 1,855 to 2,404 baht in the same case scenario. For the same type of procedure, the cost for outsourced surgical pack(s) is two to five times higher than that of using in-house products.</p> <p><strong><u>Conclusion:</u></strong> The cost of in-house sterile surgical drape pack production at Srinagarind hospital is lower than the cost of outsourcing equivalent products.</p> Sasithorn Ruangprasertkul Saowaluck Riratanapong Chatarat Iamthong Pakamon Ubhadip Pikul Nontapa Runchida Kingwong Copyright (c) 2020-09-08 2020-09-08 35 5 624 631 Nutritional Status Assessment of Cancer Patients <p>Cancer progression and cancer treatment could affect the nutritional status of cancer patients. Nutritional assessment of cancer patients will know the nutritional status of the patients &nbsp;that have normal, under or over nutrition. The nutritional assessment of cancer patients consists of nutritional screening by Malnutritional Screening Tool, food intake, anthropometric, clinical and dietary intake assessments. &nbsp;</p> Chintana Suwittawat Copyright (c) 2020-09-08 2020-09-08 35 5 632 638 Screening and Management for Latent Tuberculosis Infection (LTBI) in Household Contacts <p>Tuberculosis (TB) remains the global health problem and the most common cause of death among communicable diseases. Household contacts with active pulmonary TB patients have a chance to develop active TB disease or latent tuberculosis infection (LTBI) more than general population. Contact cases who have fever, cough, weight loss should be investigated for active TB disease by chest radiograph and sputum acid fast bacilli (AFB) staining. Contact cases who have no symptoms, normal chest radiograph and negative sputum AFB smear should be further investigated for LTBI by tuberculin skin test (TST) or interferon-gamma release assay (IGRA). Household contacts who have LTBI are at risk of progression to TB disease especially in young children and immunocompromised host. Recommended regimen for LTBI treatment included: 6 months of daily isoniazid monotherapy, 3-4 months of daily rifampicin monotherapy, 3-4 months of daily rifampicin plus isoniazid, and 3 months of weekly rifapentine plus isoniazid. The shorten regimens have noninferiority efficacy compared with 6 months of daily isoniazid monotherapy, but have much better compliance and completed treatment. Therefore, the early detection and treatment of LTBI in household contact with pulmonary TB patients is crucial to reduce the risk of developing active TB disease and impact of decreasing incidence of global TB infection.</p> Jatuporn Wanchaitanawong Wipa Reechaipichitkul Apichart So-ngern Copyright (c) 2020-09-08 2020-09-08 35 5 639 648