GAS CHROMATOGRAPHY-MASS SPECTROMETRY CHEMICAL PROFILING AND ANTIOXIDATION ACTIVITY OF THE THAI HERBAL FORMULA “PIKAD TRISUKKHATI SAMUTHARN” EXTRACT

2023-12-02T19:20:27+07:00

Pikad Trisukkhati Samutharn (PTS) is a medicinal formula used in Thai traditional medicine for treating severe fever, inflammation, and diarrhea, as well as for general health promotion. This herbal formula was made from the roots of three plants: Oroxylum indicum (L.) Kurz, Sesbania grandiflora (L.) Pers and Ficus racemosa L. The purpose of this study was to investigate the antioxidation activity and chemical profiling of PTS and its herbal components. The antioxidation activity of the extracts was determined using the DPPH free radical scavenging assay, as well as the Folin-Ciocalteu method, to investigate the total phenolic contents. The thiobarbituric acid reactive substance (TBAR) assay was used to test lipid peroxidation activity. The chemical profiling of PTS was demonstrated using gas chromatography–mass spectrometry (GC-MS) analysis. The results revealed that the total phenolic content of the ethanolic extract (79.57 ± 2.33 mg GAE/g extract) was greater than that of the aqueous extract (12.55 ± 2.83 mg GAE/g extract) of the PTS. The DPPH free radical scavenging activity of the PTS ethanolic extract (IC₅₀ value 80.69 ± 0.40 mg/mL) was also stronger than that of the PTS aqueous extract (IC₅₀ value
650.10 ± 98.20 mg/mL). Lipid peroxidation of the PTS ethanolic extract was moderate with 32.47 ± 0.71% inhibition. GC-MS revealed the presence of several phenolic compounds contained in the PTS ethanolic extract in which the identified compounds had previously been reported to have several pharmacological activities such as antioxidation, anti-inflammation, and antimicrobial. In conclusion, the antioxidation and chemical constituents of the PTS extract were demonstrated for the first time, and more pharmacological activities of PTS should be explored to confirm its traditional use.

DEVELOPMENT OF ADMISSION MEDICATION RECONCILIATION IN SONGKLANAGARIND HOSPITAL

2023-12-21T21:35:02+07:00

Hospitalized patients are prone to medication errors (MEs) which usually occur at transition points during care. Communication problems or the transfer of information between patients and healthcare professionals are among the causes of MEs. This study developed a medication reconciliation system with pharmacists who were specifically responsible for identification of medication discrepancy and intervention. This action research on patient admissions at Songklanagarind Hospital between October 2018 - September 2022 is divided into 4 phases: 1. Designed and developed medication reconciliation system with pharmacists in collaboration with a multidisciplinary team. 2. Conducted trial with one pharmacist and piloted it among patients with a previous history of using warfarin. 3. Developed medication reconciliation program. 4. Expanded the program to patients who are at risk of MEs by increasing the number of pharmacists to two. 70-78% of patients had medication reconciliation processed by a pharmacist within 24 hours of hospital admission. Pharmacists found MEs of 11-17%, with the most common being the incorrect dosage or frequency of medication (50-70%), followed by omission (15-45%). In 70-77% of the MEs, the medication did not reach the patient. Pharmacists have an important role in preventing MEs by reconciling medications. Through the medication reconciliation process, pharmacists can assess the completeness and accuracy of medication lists to reduce MEs and prevent those errors from affecting patients.

Thai Bulletin of Pharmaceutical Sciences

GAS CHROMATOGRAPHY-MASS SPECTROMETRY CHEMICAL PROFILING AND ANTIOXIDATION ACTIVITY OF THE THAI HERBAL FORMULA “PIKAD TRISUKKHATI SAMUTHARN” EXTRACT

DEVELOPMENT OF ADMISSION MEDICATION RECONCILIATION IN SONGKLANAGARIND HOSPITAL