https://li01.tci-thaijo.org/index.php/ThaiJToxicol <p style="text-align: right; color: darkblue;">ISSN 0857-264X (Print) ISSN 2697-6307 (Online)</p> <p><strong>Thai Journal of Toxicology (Thai J Toxicol)</strong> is a peer-reviewed journal publishing original research and review articles on the area of toxicology. Areas such as clinical toxicology, pharmacological toxicology, environmental toxicology, occupational health and safety of exposure to toxins, toxicity of natural products and traditional medicines, food and nutrition toxicology, safety evaluation of novel foods and ingredients, biotechnologically-derived products, nanomaterials, hazard identification and health risk assessment, adverse effects of chemically induced toxicity on the health of humans and animals, molecular toxicology, and other areas of toxicological research in vitro / in vivo models and human studies are included in the scope of the journal. Thai J Toxicol is now being indexed in <strong>Thai Journal Citation Index (TCI) Tier 1</strong></p> <p><em>The Official Journal of Thai Society of Toxicology</em></p> Thai Society of Toxicology สมาคมพิษวิทยาแห่งประเทศไทย en-US Thai Journal of Toxicology 0857-264X https://li01.tci-thaijo.org/index.php/ThaiJToxicol/article/view/265955 <p>β-1,3/1,6-Glucan, a common functional ingredient in dietary supplements, is usually produced from left-over yeast in the bakery industry with low purity. Owing to gluten-free and high-purity advantages, new cost-effective biotechnology has recently manufactured β-glucan from fungi as an alternative. However, it is a novel food and the safety limit for human consumption is unknown. This dose-escalation study aimed to evaluate the safety and tolerability of β-1,3/1,6-glucan polysaccharides and oligosaccharides from <em>Ophiocordyceps dipterigena</em> BCC 2073 in healthy subjects and identify the maximum tolerated dose (MTD). In the single ascending dose phase, 12 participants consumed either β-glucan polysaccharides or oligosaccharides capsules (n = 6 each) one dose for one day in a stepwise dose escalation from 2 to 2,000 mg (total of 14 days). In the multiple ascending dose phase, 26 participants consumed either β-glucan polysaccharides (n = 12) or oligosaccharides (n = 14) one dose daily for 2 weeks in a stepwise escalation from 2 to 2,000 mg (total of 12 weeks). The safety and tolerability were assessed by using subject diaries and blood chemistry. Results show no serious adverse events in all participants throughout the study. More frequent defecation and liquid stool were found in the β-glucan polysaccharide (16%) than in the oligosaccharide group (7%). The average blood biochemical values are all in the normal range. This study suggests that the short-term maximum tolerated dose of β-glucan polysaccharide or oligosaccharide from <em>O. dipterigena </em>BCC 2073 is 2,000 mg per day. Further long-term safety trials are warranted.</p> Niramol Muangpracha Numphung Rungraung Wai Prathumpai Dunyaporn Trachootham Copyright (c) 2025 Thai Journal of Toxicology 2025-03-20 2025-03-20 40 1 1 28 https://li01.tci-thaijo.org/index.php/ThaiJToxicol/article/view/266801 Editorial team Copyright (c) 2025 Thai Journal of Toxicology 2025-01-01 2025-01-01 40 1