https://li01.tci-thaijo.org/index.php/gst/issue/feed Genomics and Genetics 2022-12-26T17:54:45+07:00 Associate Professor Dr. Theerachai Thanananta editor.tjg@gmail.com Open Journal Systems <p style="text-align: justify;"><strong>Genomics and Genetics (G&amp;G)</strong>, formerly Thai Journal of Genetics, is an official peer-reviewed international scientific journal of <strong>The Genetics Society of Thailand (GST)</strong>. G&amp;G is an online open access journal, which publishes review articles, research articles, and short communications in all fields of Genomics and Genetics, including human genetics, medical genetics, forensic genetics, cancer genetics, pharmacogenetics, behavioral genetics, developmental genetics, animal genetics, plant genetics, agricultural genetics, microbial genetics, population genetics, evolutionary genetics, archaeogenetics, cytogenetics, biochemical genetics, molecular genetics, genomics, transcriptomics, proteomics, metabolomics, bioinformatics, and systems biology.</p> <p style="text-align: justify; background: white; margin: 0cm 0cm 7.5pt 0cm;">Manuscript in conformity with the scope of the journal and substantially contributing to the fields of genomics, genetics, and related subjects is considered for publication in G&amp;G. The manuscript submitted to G&amp;G is original, previously unpublished, research or review article containing a high quality of content that is scientifically sound. The acceptance of manuscript for publication is judged by the Editor, Editorial Board, and two or more external reviewers, based on the quality, soundness, and overall presentation of the manuscript.</p> <p style="text-align: justify; background: white; margin: 0cm 0cm 7.5pt 0cm;"><span style="background: white;">In addition, an important consideration criterion for the acceptance of manuscript for publication in G&amp;G is that the manuscript is written in a clear and grammatically correct academic English. </span>It is recommended that before submission to G&amp;G, the manuscript should be edited by a native English speaker who is familiar with scientific or academic English. The well written manuscript that has been edited by a native English speaker is accelerated to the peer-review process. The manuscript that is poorly written and <span style="background: white;">grammatically incorrect</span> is subjected to rejection without entering the peer-review process.</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;"><strong>Peer review process of G&amp;G is double blinded.</strong></p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;">&nbsp;</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;"><strong>Publication ethics of G&amp;G <span style="background: white;">follows the principles outlined by the </span>Committee on Publication Ethics (COPE)</strong>; <a href="https://publicationethics.org/"><span style="color: windowtext;">https://publicationethics.org/</span></a>. The result of plagiarism check is needed to append with the manuscript in the submission step.</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;">G&amp;G is indexed by Thailand Citation Index (TCI) Group 2.</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;">G&amp;G follows an Open-Access policy. Articles are made available in full content at https://www.tci-thaijo.org/index.php/gst/index. Back issues dating to 2008 are available through this site</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;">&nbsp;</p> <p style="background: white; margin: 0cm 0cm 7.5pt 0cm;">Editor-in-Chief: Pa-thai Yenchitsomanus</p> https://li01.tci-thaijo.org/index.php/gst/article/view/253930 BCR-ABL1 Fusion Patterns Identified by Fluorescence in situ Hybridization (FISH) in Chronic Myeloid Leukemia (CML) 2022-08-28T13:58:47+07:00 Nisakorn Klinkularb nisakorn.kli@mahidol.ac.th Veerawat Korkiatsakul chaicub@hotmail.com Pitichai Phornsarayuth nexus.rupy@gmail.com Takol Chareonsirisuthigul takol.cha@mahidol.ac.th Budsaba Rerkamnuaychoke budsaba.rer@mahidol.ac.th <p><em>BCR-ABL1 </em>gene rearrangement is believed to be the most common molecular genetic abnormality in chronic myeloid leukemia (CML). This fusion has been assessed using the fluorescence<em> in situ</em> hybridization (FISH) technique. This study aimed to identify the FISH signal patterns observed in a large cohort of patients in order to provide the necessary information and a guideline for CML treatment. Blood or bone marrow samples from 431 patients diagnosed as suspected CML were processed by standard FISH procedures for identifying <em>BCR-ABL1</em> translocation using XL BCR-ABL1 Plus Translocation/Dual Fusion Probe. One hundred forty-seven samples (34.11%) were positive for <em>BCR-ABL1 </em>fusion, while 284 cases (65.89%) were negative. For positive <em>BCR-ABL1 </em>fusion, the typical signal pattern was seen in 103 patients (70%). Atypical signal patterns were found in the remaining 44 cases (30%) which included 8.84% of multiple patterns. Besides, we also found 0.68% deletion of <em>BCR</em> locus, 1.36% three copies of <em>ABL1</em>, and 0.68% four copies of <em>BCR</em> with four copies of <em>AML1</em>. For CML, the FISH assay has an advantage to support diagnosis, especially in the laboratory that cannot have the facility to perform karyotyping. Therefore, monitoring the <em>BCR-ABL1 </em>signal pattern identified by FISH is an effective way to provide prognostic guidance and treatment options for CML patients and can be used to predict disease progression and relapse.</p> 2022-12-26T00:00:00+07:00 Copyright (c) 2022 https://li01.tci-thaijo.org/index.php/gst/article/view/256931 Potential Role of Peptide Transporter2 Gene in Salt Stress 2022-11-23T15:52:24+07:00 Achmad Syarifudin achmadd.syarifudin@gmail.com Supachitra Chadchawan s_chadchawan@hotmail.com <p>The Thai rice cultivar 'Luang Pratahn' is a promising candidate for a salt-tolerant donor plant. Previously, several key genes responsible for salt tolerance were identified using time-course transcriptomic data and weighted co-expression networks. The rice peptide transporter2 (<em>OsPTR2</em>) gene is one of the key genes with no prior information related to the salt tolerance mechanism in rice. Salt stress could induce <em>OsPTR2</em> gene expression in salt tolerant cultivars, 'Pokkali' and 'Luang Pratahn', while it couldn’t be induced in IR29, the salt susceptible line, suggesting the possibility of <em>OsPTR2</em> involvement in salt tolerance. Therefore, this research aims to investigate the role of PTR2 gene in salt stress response by using the <em>OsPTR2</em> orthologous gene in Arabidopsis, <em>AtPTR2</em>. Based on bioinformatic analysis, <em>OsPTR2</em> and <em>AtPTR2 </em>are transmembrane proteins and share 5 similar domains. Therefore, the homozygous line of <em>Atptr2 </em>knocked-out mutant line was used to investigate the involvement of <em>Atptr2 </em>gene in salt stress response. After 7 days under salt stress condition, <em>Atptr2 </em>mutant showed the significantly shorter root length and lower dry weight than wild type (WT), without significant difference in photosynthetic pigment contents between the mutant and WT. These results suggested that <em>Atptr2 </em>had a potential role in root development under salt stress condition. The revertant of <em>Atptr2 </em>mutant by <em>OsPTR2 </em>expression will be done for further characterization.</p> 2022-12-29T00:00:00+07:00 Copyright (c) 2022