TY - JOUR AU - Sriraksa, Napatr AU - Hawiset, Thaneeya AU - Khongrum, Jurairat PY - 2019/12/27 Y2 - 2024/03/29 TI - Effects of Moringa Oleifera Leaf Extract on the Acetylcholinesterase and Monoamine Oxidase Activities in Rat Brains with Streptozotocin-Induced Diabetes and Sciatic Nerve Constriction JF - Health Science, Science and Technology Reviews JA - Health Sci Tech Rev VL - 12 IS - 3 SE - Research articles DO - UR - https://li01.tci-thaijo.org/index.php/journalup/article/view/188720 SP - 13-22 AB - <p>Cognitive decline in diabetes is related to hyperglycemia-induced cerebral metabolism of neurotransmitters that play a role in cognitive function. This study aimed to determine the effect of <em>Moringa oleifera</em> (<em>M. oleifera</em>) leaf extract on the activities of acetylcholinesterase (AChE) and monoamine oxidase (MAO) in diabetic rat brains with a sciatic nerve constriction. Type-I diabetes was induced in young adult male Wistar rats (180-220 g) with a single injection of streptozotocin (STZ) at a dose of 65 mg/kg BW (i.p.). The diabetic rats were further subjected to a right sciatic nerve constriction. Then, rats were randomly assigned to three different doses of orally administered <em>M. oleifera</em> leaf extract (100, 200 and 300 mg/kg BW) for 21 days. The cerebral cortex, hippocampus, and striatum were collected to determine the activities of AChE and MAO. The results showed that <em>M. oleifera</em> leaf extract significantly decreased the activity of AChE and MAO in the studied brain regions.</p> ER -