TY - JOUR AU - คำแก้ว, ณฐกร AU - ผจญภัย, วาทิตา AU - รมสาร, ศศิวิมล AU - เขียวสีมา, ปภาอร AU - พิทักษ์พล, วาสนา AU - ชูทิพย์, กรองกาญจน์ PY - 2019/04/26 Y2 - 2024/03/29 TI - Antihypertensive effects of Ma-kiang fruit extract on hypertensive rats JF - Health Science, Science and Technology Reviews JA - Health Sci Tech Rev VL - 12 IS - 1 SE - Research articles DO - UR - https://li01.tci-thaijo.org/index.php/journalup/article/view/213565 SP - 5-9 AB - <p>The aim of this study was to investigate the acute and chronic effects of Ma-kiang fruit extract on blood pressure in L-NAME induced hypertensive rats. We found significant reduction of blood pressure in a dose-dependent manner through intravenous injection of the extract (20, 40 and 60 mg/kg). Moreover, the chronic oral administration of the extract (500 mg/kg/day) for 6 weeks in hypertensive rats showed the significant attenuation of hypertension, and did not significantly decreased heart rate.</p> ER -