TY - JOUR AU - Pechroj, Sirintip AU - Potiparsat, Kamonporn AU - Nangam, Oraphan AU - Athipornchai, Anan AU - Suriyaphan, Jariyavadee AU - Muangham, Sophawadee AU - Srisook, Klaokwan PY - 2020/12/25 Y2 - 2024/03/29 TI - Comparative evaluation of antioxidant and anti-Inflammatory activities of four seaweed species from the east coast of the Gulf of Thailand JF - Health Science, Science and Technology Reviews JA - Health Sci Tech Rev VL - 13 IS - 3 SE - Research articles DO - UR - https://li01.tci-thaijo.org/index.php/journalup/article/view/245541 SP - 11-21 AB - <p>Seaweeds are good sources of bioactive secondary metabolites, with utilizations in medicine and the food industry. However, information on the biological activities of seaweed harvested from the east coast of the Gulf of Thailand are limited. We, therefore, conducted a comparatively study on antioxidant and anti-inflammatory activities of four seaweed species (<em>Dictyota cervicornis</em>, <em>Sargassum polycystum</em>, <em>Padina australis</em> and <em>Caulerpa lentillifera</em>) collected from Sattahip District, Chonburi Province. <em>In </em><em>vitro</em> antioxidant screening was performed based on DPPH radical scavenging and metal ion chelating activities. Cell-based antioxidant activities were evaluated based on the formation of reactive oxygen species (ROS) by dichlorofluorescein (DCF) assay. Anti-inflammatory activity was determined by assessing suppression of nitric oxide (NO) production in LPS-induced macrophages. Among all seaweed species examined, <em>P. australis</em> was the most active as a DPPH scavenger, whereas <em>P. australis</em> and <em>D. cervicornis</em> showed the highest metal chelating activity. Furthermore, <em>D. cervicornis</em> showed the greatest inhibitory activity on ROS and NO production in LPS-stimulated macrophages. Phytochemical screening tests demonstrated the presence of steroids in all four seaweeds. Tannins were found in <em>P. australis</em> and <em>D. Cervicornis</em> and terpenoids in <em>D. Cervicorni</em>s. These results suggest all four seaweeds, especially <em>D. cervicornis</em>, are natural sources of antioxidants and anti-inflammatory agents with potential applications in the food and medical industries.</p> ER -