Evaluation of Antioxidant Capacity, Tyrosinase Inhibition, and Antibacterial Activities of Brown Seaweed, Sargassum ilicifolium (Turner) C. Agardh 1820 for Cosmeceutical Application

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Eldrin De Los Reyes Arguelles

Abstract

Seaweeds are a rich source of active compounds with excellent biological activities that are useful for formulation of cosmetic products. The investigation aims to study the biological and skin protection activities of Sargassum ilicifolium extract by evaluating its ability to scavenge free radicals, copper reducing capacity, tyrosinase inhibition and antibacterial properties. The results showed that S. ilicifolium extract has a total phenolic content of 4.86±0.07 mg GAE·g-1. Analysis of the antioxidant capacity of S. ilicifolium extract exhibited potent DPPH (diphenyl-1, 2-picryl hydrazyl) radical scavenging activity and high capacity of reducing copper ions in a concentration-dependent manner, with IC50 values of 15.78 μg·mL-1 and 11.19 μg·mL-1, respectively. Also, S. ilicifolium extract showed tyrosinase inhibition activity, with IC50 of 40.50 μg·mL-1, more effective than that obtained for kojic acid with IC50 of 109.8 μg·mL-1. In addition, potent antibacterial activity was exhibited by S. ilicifolium extract against common skin pathogenic bacteria such as Methicillin-resistant Staphylococcus aureus, Staphylococcus aureus and Staphylococcus epidermidis, with minimum inhibitory concentration (MIC) values of 125 μg·mL-1, 125 μg·mL-1, and 250 μg·mL-1, respectively. This study clearly demonstrates the effective biological and skin protecting properties of Sargassum ilicifolium as an alternative source of active ingredients useful for cosmeceutical application.

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