Maternal-Fetal and Neonatal Clinical Characteristics of Down Syndrome at Srinagarind Hospital
Keywords:
Down syndrome; Characteristic; Maternal; Fetal; Neonatal; กลุ่มอาการดาวน์ ลักษณะทางคลินิก; มารดา; ทารกในครรภ์; ทารกแรกเกิดAbstract
Objective: To describe maternal-fetal and neonatal clinical characteristics of Down
Syndrome (DS) at Srinagarind Hospital.
Materials and Methods: The present study was a retrospective descriptive study. The
authors recruited all pregnant women who delivered babies with DS at Srinagarind hospital
between January 1, 1993 and December 31, 2012. Histories of all participants were obtained from medical records. Clinical characteristics of them were recorded in case record form (CRF). The statistics used to describe the clinical characteristics were percentage.
Results: The incidence of DS at Srinagarind hospital was 0.61 in 1,000 of total births. 57% of pregnant women who delivered babies with DS are 35 years or older. 52% delivered before term gestation and had no abnormal obstetric history in previous pregnancies. Only 18% had definite prenatal diagnosis. DS babies occur more frequently in infants of diabetic mothers. The most common ultrasonographic finding of the fetuses with DS in our study was asymmetrical intrauterine growth restriction. For full term neonates with DS, the average value of head circumference was slightly smaller than normal.
Conclusion: Incidence of DS at Srinagarind Hospital was 0.61 in 1000 of total births.
In this study, advanced maternal age and maternal gestational DM, probably, may be the important risk factors of having a child with DS. Definite prenatal diagnosis was still
lower rate. For neonatal clinical characteristics, head circumferences were smaller in DS
babies.
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