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Cholangiocarcinoma (CHCA) is the most commoncancer in Thailand, especially in the Northeastern region.From population-based cancer registry in Khon Kaen, theincidence of CHCA is evidently high in area located nearwater reservoir with the liver fluke, Opisthorchis viverrini,contamination in the fish. The trend in incidence of CHCAin Khon Kaen has been slowly declining in both sexeswith annual percent age changes of 0.7% and 0.4% inmale and female, respectively. The survival rate of patientwith CHCA is very low according to ineffective treatmentmodalities. Thus, prevention of liver fluke infection tohuman is the most effective strategy. The campaignagainst the fluke infection must be intensively implementedunder the national policy.
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