Epigenetics in Cholangiocarcinoma

Authors

  • Ruethairat Sriraksa - Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand
  • Temduang Limpaiboon - Centre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand - Liver Fluke and Cholangiocarcinoma Research Center, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

Keywords:

การควบคุมเหนือพันธุกรรม, มะเร็งท่อน้ำดี, ดีเอ็นเอ เมทิลเลชัน, การดัดแปลงโปรตีนฮิสโทน, ไมโครอาร์เอ็นเอ, มะเร็ง, epigenetics, cholangiocarcinoma, DNA methylation, histone modifications, microRNAs, cancers

Abstract

Although genetic defects have been widely documentedthe association to pathogenesis of cholangiocarcinoma(CCA), epigenetic aberrations have also been focused inCCA. Those epigenetic deregulations include promoterhypermethylation, hypomethylation, histone modifications,and up- or down-regulation of microRNAs. In this review,we summarize the role of epigenetic mechanisms whichregulate normal and cancer cells, especially in CCA.This information could indicate that the study anddevelopment of new epigenetic biomarkers for earlydetection and prediction are necessary in CCA. In addition,an application of widely-used demethylating agents andhistone deacetylase inhibitors has been also discussedto provide a potential chemotherapeutic strategy andeffectiveness for CCA.

Keywords : epigenetics, cholangiocarcinoma, DNAmethylation, histone modifications, microRNAs, cancers

Downloads

How to Cite

1.
Sriraksa R, Limpaiboon T. Epigenetics in Cholangiocarcinoma. SRIMEDJ [Internet]. 2013 Aug. 23 [cited 2024 Jun. 22];27:381-8. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/11163

Issue

Section

Review Articles