Factors Affecting Microalbuminuria in Type 2 Diabetes: Meta-analysis

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Sirima Mongkolsomlit
Petch Rawdaree

Abstract

Background and objective : There were many articles determined factors associated with microalbuminuria in type 2 diabetes. Some articles reported the same result, some articles reported difference. It was confusing which is to apply for prevention and health promotion in public health and clinical practice. The aim of this study was to determine factors associated with microalbuminuria in type 2 diabetes by meta-analysis.

Methods : We performed our search using Ovid MEDLINE, Scopus, BMJ Clinical Evidence, ProQuest, Thai index medicus and Thai Medical index. The study design  was an analytical cross sectional study and detection of microalbuminuria by quantitative technique, published during 1992 -2009. Criteria of quality assessment for publication composed of microalbuminuria classification and urine collection method. Heterogeneity assessment for the studies’ results was the use of Cochran’s c2.

Results : Of 2,428 identified articles on electronic database, 17 articles were included for the analysis because of selection criteria and quality assessment criteria. The data was extracted and converted to be a standard measurement unit. Pooled effect estimates were obtained by using fixed effect and random effect meta-analysis. This study found that age, duration of diabetes, smoking, high blood pressure, high blood plasma glucose and dyslipidemia were the risk factors associated with microalbuminuria. But there is only HDL that expresses the protective factor of microalbuminuria (OR = 0.850, 95% CI = 0.748-0.966), p-value = 0.013).

Conclusion : The health promotion program to prevent microalbuminuria in type 2 diabetes should be considered the behavioral optimization programming such as stop smoking programs, blood pressure control, blood glucose control and nutrition education.

Keywords : microalbuminuria , diabetes, meta analysis

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