Does Cardiac Autonomic Modulation Exist in Obese Adolescents?

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Wilaiwan Khrisanapant
Phouvang Sengmeuang
Orapin Pasurivong
Upa Kukongviriyapan

Abstract

Background: Previous studies regarding the effect of obesity on cardiac sympathetic-parasympathetic balance in adolescents remain unclear.

Objectives: To examine the cardiac autonomic activity (CAA) in adolescent obesity using spectral heart rate variability (HRV).

Methods: A body mass index (BMI) greater than 95th and more than 5th but less than 85th percentile according to age and sex were accepted as obesity and normal weight, respectively. None of the subjects had clinical evidence of cardiopulmonary disease. Low frequency (LF)(0.04-0.15 Hz) and high frequency (HF)(0.15-0.4 Hz) spectral powers, LF and HF in normalized units (n.u.), and the ratio of LF to HF were used as the conventional indices of HRV to measure CAA. HRV (all as mean ± SD) (median) was measured for 5 minutes in the supine position after 10 minutes of rest in the same position.  The subjects were 23 obese adolescents (9 male), aged 12 to 17 years, and 24 normal-weight peers (6 male).

Results: The averaged values of the BMI of obese and healthy subjects were 33.9±5.0 kg/m2 (median 33.0) and 20.5±1.6 kg/m2 (median 20.3) (p<0.001), respectively. The spectral power was quantified in total power (TP), very low-frequency power (VLF), low-frequency power (LF), high-frequency power (HF) and LF to HF ratio. LF and HF expressed in normalized unit were also calculated. When compared with healthy adolescents, no significant reductions were observed in; R-R interval, TP, VLF, LF, HF and LF/HF in obese adolescents.

Conclusions: There was no cardiac autonomic modulation as a consequence of obesity in adolescents. Our findings do not support the conclusion that obesity increases sympathetic activation and/or reduces parasympathetic tone.

Key words: heart rate variability, cardiac autonomic modulation, adolescent obesity

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1.
Khrisanapant W, Sengmeuang P, Pasurivong O, Kukongviriyapan U. Does Cardiac Autonomic Modulation Exist in Obese Adolescents?. Srinagarind Med J [nternet]. 1 [cited 2021Nov.29];23(3):234-9. vailable from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/13077
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