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Background: Diabetes is a condition which is known to be associated with a variety of connective tissue abnormalities which contribute to impair wound healing, leading to the chronic ulcer formation. Centella asiatica Linn. and Garcinia mangostana Linn. are widely used as Thai traditional medicine including wound treatment. However, the effects of both plant extracts in diabetic condition are still unclear.
Objective: To study the effects of topical administration of Centella asiatica Linn. and Garcinia mangostana Linn. on diabetic wound.
Materials and Methods: Male Spraque-Dawley rats (64 rats) were divided into 2 groups: Normal control and diabetes group, each group was divided into 4 groups. Created wound and treatment of wounds by placebo, neomycin and both plant extracts.
Results: Showed that the faster of wound epithelialized and higher of wound contraction rate in the groups of treated with both plant extracts when compare with non treated groups.
Conclusion: The present results confirmed the folkloric utilization and suggested the beneficial effects of both plant extracts for treating diabetic wounds in human being. However, the further studies with purified constituents were required to understand the complete mechanism of wound healing promotion induced by both Centella asiatica Linn. and Garcinia mangostana Linn.
Key words: wound healing, diabetes, Centella asiatica Linn., Garcinia mangostana Linn.