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The authors reported a 16 year-old Thai girl who presented with upper gastrointestinal bleeding, high fever and left upper quadrant abdominal pain. The preoperative diagnosis of isolated splenic vein thrombosis was confirmed by percutaneous sphenoportography. Splenectomy was performed. She has not bled during her 1 year period of follow-up. Criteria of diagnosis and pathophysiology of this condition will be discussed in details.
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