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Acute febrile neutrophilic dermatosis (Sweet’s syndrome) is an uncommon, recurrent skin disease of unknown etiology characterized by painful inflammatory plagues with fever, arthralgia and leucocytosis. Many associated systemic diseases were reported. In this report we described a classical case of Sweet’s syndrome in association with Salmonella empyema and tuberculous lymphadenitis. Diagnostic approaches, clinical course and outcome were discussed in detail.