A Compartive Study of Clemastine Fumarate, Mebhydrolin Napadisylate and Placebo in the Symptomatic Treatment of Perennical Allergic Rhinitis

Abstract

H-receptor antagonist still play an important role in the symptomatic controls of allergic rhinitis. This study was conducted to evaluate the efficacy and side-effects of two H-receptor antagonists namely, mebhydrolin which is one of the most widely used antihistamines and clemastine, a long-acting antihistamine. Placebo was used as a control group. There were one hundred and six patients participating in this study which was a randomized double-blind paralled trial. The results indicated that both mebhydrolin and clemastine are effective in controlling the symptoms of allergic rhinitis , e.g. sneezing nasal blockade and rhinorrhea When these two drugs were compared, clemastine was shown to be superior to mebhydrolin in global improvement. However, the response to H-receptor antagonist varies from patient to patient , thus we should try first and then select the right one for the right patient.