A Compartive Study of Clemastine Fumarate, Mebhydrolin Napadisylate and Placebo in the Symptomatic Treatment of Perennical Allergic Rhinitis

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Somchart Saengsa-ard
Pinit Lunchanavanit

Abstract

H-receptor antagonist still play an important role in the symptomatic controls of allergic rhinitis. This study was conducted to evaluate the efficacy and side-effects of two H-receptor antagonists namely, mebhydrolin which is one of the most widely used antihistamines and clemastine, a long-acting antihistamine. Placebo was used as a control group. There were one hundred and six patients participating in this study which was a randomized double-blind paralled trial. The results indicated that both mebhydrolin and clemastine are effective in controlling the symptoms of allergic rhinitis , e.g. sneezing nasal blockade and rhinorrhea When these two drugs were compared, clemastine was shown to be superior to mebhydrolin in global improvement. However, the response to H-receptor antagonist varies from patient to patient , thus we should try first and then select the right one for the right patient.

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How to Cite
1.
Saengsa-ard S, Lunchanavanit P. A Compartive Study of Clemastine Fumarate, Mebhydrolin Napadisylate and Placebo in the Symptomatic Treatment of Perennical Allergic Rhinitis. SRIMEDJ [Internet]. 2013 Nov. 11 [cited 2024 Mar. 29];3(2):82-9. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/13445
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