-Lactamases and -Lactamase inhibitors

Abstract

b-Lactamases are the major enzymatic mechanism of most resistant bacteria.  They found in many kinds of the pathogen which may be constitutive or inducible.  Sulbactam and clavulanic acid are the most ideal b-Lactamase inhibitors which inhibit enzyme class II, III, IV and V of Richmond and Sykes classification.  The inhibitors are effectively reduced the MIC of amoxycillin or ampicillin in clinical usage

Key word : b-Lactamases and b-Lactamase inhibitors