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Dyspepsis is an extremely common presenting symptom with a prevalence in the community of approximately 30% and may be an early symptom of a serious illness. This prospective data analysis aims to determine the etiology of the patient who present with dyspepsia in Srinagarind Hospital. 208 patients were studied with completed a structured history questionnaire and completed investigation with complete blood count, stool examination, liver function test, HbsAg, HbsAb, ultrasonography of the abdomen and endoscopy. The most common cause is non-ulcer dyspepsia (53.27%). There were peptic ulcer disease in 26.44%, hepatobiliary disease in 16.83% and combined peptic ulcer disease and hepatobiliary disease in 3.37%. Malignant cause of dyspepsia which we found in this series is tumor of the liver.
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