A Study on Immune Response to Cryptococcus Neoformans Antigens in Rabbits

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Srivilai Varopastrakul
Ganjana Lertmemongkolchai
Nareas Waropastrakul
Arunrat Romphruk


A study on immune response to Cryptococcus neoformans antigens was done in rabbits.  Three different doses of encapsulated C. neoformans antigens, 1.5x107, 1.5x108 and 1.5x109 cells/milliliter respectively, were injected intravenously via ear vein.  Results showed that the concentration of 1.5x108 cells/milliliter stimulated high agglutination titers of antibody i.e., 1024 in one rabbit and 32768 in the other.  For comparison, the titer of antiserum obtained from rabbits immunized with 1.5x107 cells/milliliter did not exceed 64, while the dose of 1.5x109 cells/milliliter killed rabbits.  Results suggested that a high quantity of anti-C. neoformans antiserum could be prepared in rabbits.  This antiserum would be an important reagent in the development of the serological test kit for Cryptococcal diagnosis.

KEY WORD : Cryptococcus neoformans, Antibody response.


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Varopastrakul S, Lertmemongkolchai G, Waropastrakul N, Romphruk A. A Study on Immune Response to Cryptococcus Neoformans Antigens in Rabbits. SRIMEDJ [Internet]. 2013 Nov. 11 [cited 2022 Aug. 13];6(2):101-6. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/13566
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