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A 61-year-old woman was referred to Srinagarind Hospital Khon Kaen University because of SVC obstruction. Echocardiography revealed a sizable tumor in RA, RV. outflow tract, main pulmonary artery and right pulmonary artery. All parts of the tumor were successfully excised and the patient was recovered uneventfully. The histological examination of the tumor revealed liposarcoma. This report emphasizes that intracardiac tumor, liposarcoma, should be included in differential diagnosis of SVC obstruction syndrome.