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Phlai (Zingiber cassumunar ROXB.) is an indigenous Thai medicinal herb famous as an antiinflammatory remedy. Essential oil from this plant rhizome has been extracted and developed into a opical cream (14% phlai oil) Known as Plygesal. This double – blinded randomized cotrolled joint motions after an ankle for 7 – day daily assessments. For the ten Plygesal - treated ankles, applications of the cream twice daily significantly (p < 0.05) reduced the severity of swelling. Patients became less painful (tested by visual analogue scale) than controls after four days and taking less analgesics (paracetamol) during the first two days. The treated ankles could dorsiflex more then the placebo group, but magnitude of plantar flexion were not different between both groups. In conclusion, this phlai cream is efficacious in reducing symptoms and signs of ankle sprain that joint stability has not been violated.