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A 41 year-old married Thai male patient had history of asthma 8 months ago. Two months later, he had recurrent asthmatic attack with hemoptysis, abdominal pain, diarrhea and generalized purpura. Five months after that he had progressive paresthesia and weakness all extremities and unable to walk by himself. The physical examination showed atrophy of both intrinsic hand muscles, muscle powers were grade 4/5. Deep tendon reflexes were decreased and there was asymmetrical impairment of sensation of both hands and feet. The results of investigation revealed eosinophilia, high ESR. Nerve biopsy showed acute demyelinating and axonopathy. He improved after steroid treatment.
CSS is more common in male than female. All patients have asthma, systemic vaculitis and eosinophilia. CSS has the multisystem involvement, monoeuritis multiplex, abdominal pain cutaneous vasculitis. heart failure and arthritis. Diagnosis base on criteria four of six; asthma, eosinophilia> 10%, neuropathy, nonfixed pulmonarty infiltration, paranasal sinus abnormality and extra vascular eosinophils. CSS usually respond to steroid treatment.
We report a case of CSS and review related literature