Symptom Clusters in Patients with Bladder Cancer: A Secondary Analysis
Keywords:
Bladder cancer; Symptom clusters; Symptom managementAbstract
Background and Objective: Patients with cancer often have experience of multiple symptoms, which are called symptom clusters, due to the consequence of disease or treatment. Study of symptom clusters may lead to effective management in patients suffering from such symptoms. The aim of this study was to explore the symptom clusters in Thai patients with bladder cancer.
Methods: A secondary analysis of sixty-two bladder cancer patients attending a urology clinic at a Thailand university hospital was done to determine the clustering of symptoms.
Results: The majority of participants came to hospital for follow-up appointment after complete course of treatment (40.3%), BCG intravesical therapy (27.4%), chemotherapy (21.0%), and radiotherapy (11.3%). Three distinct symptom clusters were identified. First cluster: diarrhea, lack of appetite, sleep disturbance, and fatigue; second cluster: constipation, back pain; and third cluster: frequent urination, and mouth/throat sores.
Conclusion: This study can provide beneficial information for health professionals to consider about clustering symptoms of patients with bladder cancer, and could plan for symptom management more effectively.
References
Zhang X, Han C, He J. Recent advances in the diagnosis and management of bladder cancer. Cell Biochem Biophys 2015; 73: 11-5.
2. Jemal A, Bray F, Center M, Ferley J, Ward E, Forman D. Global Cancer Statistics. CA Cancer J Clin 2011; 61: 69-90.
3. Gorin MA, Ayyathurai R, Soloway MS. Diagnosis and treatment of bladder cancer: how can we improve? Postgrad Med 2012; 124:28-36.
4. Khuhaprema T, Attasara P, Sriplung H, Wiangnon S, Sangrajrang S. Cancer in Thailand. 2013. [Cited July 21, 2015]. Available from http://www.nci.go.th/th/ Filedownload/ Nci%20 Cancer%20Registry-Cancer%20in%20thailand_VII.pdf.
5. Cancer Council NSW. Staging and grading bladder cancer. 2014 [Cited September 1, 2014]. Available from http://www.cancercouncil.com.au/80616/b1000/bladder-cancer-10/staging-and-grading-bladder-cancer.
6. Pang KH, Catto JWF. Bladder cancer. Surgery 2013; 31: 523-9.
7. Levy DA. Surveillance for recurrent bladder cancer overview of bladder cancer surveillance. 2015. [Cited January 5, 2017]. Available from http://emedicine.medscape.com/article/458825-overview
8. Bajorin DF. Tumors of kidney, bladder, ureters and renal pelvis. In Goldman L, Ausiello DA, editor. Cecil medicine. (23rded). Philadelphia: Saunders Elsevier, 2008:1303- 9.
9. American Cancer Society. Bladder cancer. 2015. [Cited July 22, 2015]. Available from http://www.cancer.org/acs/groups/cid/documents/webcontent/003085-pdf.pdf.
10. Vuttanon N, Vichittragoonthavon S, Chaisurin P, Thingchai C. Symptom management for bladder cancer in Thailand. Int J Urol Nurs 2017; 11: 82-9.
11. Decaestecker K, Oosterlinck W. Managing the adverse events of intravesical bacillus Calmette-Guerin therapy. Res Rep Urol 2015; 7:157-63.
12. Brausi M, Oddens J, Sylvester R, Bono A, van de Beek C, van Andel G, et al. Side effects of Bacillus Calmette-Guérin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose and 1 year with 3 years of maintenance BCG. Eur Urol 2014; 65:69-76.
13. Goedendorp MM, Gielissen MF, Verhagen CA, Bleijenberg G. Development of fatigue in cancer survivors: a prospective follow-up study from diagnosis into the year after treatment. J Pain Symptom Manage 2013; 45:213-22.
14. Lenz ER, Pugh LC, Milligan RA, Gift A, Suppe F. The middle-range theory of unpleasant symptoms: an update. Adv Nurs Sci 1997; 19:14-27.
15. Jimenez A, Madero R, Alonso A, Martinez-Marin V, Vilches Y, Martinez B, et al. Symptom clusters in advanced cancer. J Pain Symptom Manage 2011; 42:24-31.
16. Kurtz M, Kurtz JC, Given CW, Given B. Symptom cluster among cancer patients and effects of an educational symptom control intervention. Cancer Ther 2007; 5:105-12.
17. Honea N, Brant J, Beck SL. Treatment-related symptom clusters. Semin Oncol Nurs 2007; 23:142-51.
18. Ryu E, Kim K, Cho MS, Kwon IG, Kim HS, Fu MR. Symptom clusters and quality of life in Korean patients with hepatocellular carcinoma. Cancer Nurs 2010; 33: 3-10.
19. Phligbua W, Pongthavornkamol K, Knobf TM, JUnda T, Viwatwongkasem C, Srimuninnimit V. Symptom Clusters and Quality of Life in Women with Breast Cancer Receiving Adjuvant Chemotherapy. Pacific Rim Int J Nurs Res 2013; 17: 249-67.
20. Kwekkeboom KL. Cancer symptom cluster management. Semin Oncol Nurs 2016; 32: 373-82.
21. Miaskowski C, Dunn L, Ritchie C, Paul SM, Cooper B, Aouizerat BE, et al. Latent class analysis reveals distinct subgroups of patients based on symptom occurrence and demographic and clinical characteristics. J Pain Symptom Manage 2015; 50: 28-37.
22. Yates P, Miaskowski C, Cataldo JK, Paul SM, Cooper BA, Alexander K, et al. Differences in Composition of symptom clusters between older and younger oncology patients. J Pain Symptom Manage 2015; 49: 1025-34.
23. Teunissen S, Wesker W, Kruitwagen C, de HAes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: a systematic review. J Pain & Symptom Manage 2007; 34: 94-104.
24. Poole K, Froggatt K. Loss of weight and loss of appetite in advanced cancer: a problem for the patient, the cancer, or the health professional? Palliat Med 2002; 16: 499-506.
25. Stepanski EJ, Walker MS, Schwarzberg LS, Blakely J, Ong JC, Hout AC. The relation of trouble sleeping, depressed mood, and fatigue in patients with cancer. J Clin Sleep Med 2009; 5: 132-6.
26. Roscoe JA, Kaufman ME, Matteson-Rusby SE, Palesh OG, Ryan JL, Kohli S, et al. Cancer-Related Fatigue and Sleep Disorders. The Oncologist 2007; 12: 35-42.
27. Zucca AC, Boyes AW, Linden W, Girgis A. All's well that ends well? Quality of life and physical symptom clusters in long-term cancer survivors across cancer types. J Pain Symptom Manage 2012; 43: 720-31.
28. Jacobsen PB, Andrykowski MA. Tertiary prevention in cancer care: understanding and addressing the psychological dimensions of cancer during the active treatment period. Am Psychol 2015; 70: 134-5.
29. Jones MP, Dilley JB, Drossman D, Crowell, MD. Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 2006; 18: 91-103.
30. Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, et al. Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci 2015; 9: 131.
31. Skerman HM, Yates PM, Battistutta D. Identification of cancer-related symptom clusters: an empirical comparison of exploratory factor analysis methods. J Pain Symptom Manage 2012; 44:10-22.
32. Stein A, Voigt W, Jordan K. Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol 2010; 2:51-63.
33. Gibson RJ, Stringer AM. Chemotherapy-induced diarrhea. Curr Opin Support Palliat Care 2009; 3:31-5.
34. Boltong A, Aranda S, Keast R, Wynne R, Francis PA, Chirgwin J, et al. A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. PLoS ONE 2014; 9: e103512.
35. Stanton AL, Rowland JH, Ganz PA. Life after diagnosis and treatment of cancer in adulthood: contributions from psychosocial oncology research. Am Psychol 2015; 70: 159-74.
2. Jemal A, Bray F, Center M, Ferley J, Ward E, Forman D. Global Cancer Statistics. CA Cancer J Clin 2011; 61: 69-90.
3. Gorin MA, Ayyathurai R, Soloway MS. Diagnosis and treatment of bladder cancer: how can we improve? Postgrad Med 2012; 124:28-36.
4. Khuhaprema T, Attasara P, Sriplung H, Wiangnon S, Sangrajrang S. Cancer in Thailand. 2013. [Cited July 21, 2015]. Available from http://www.nci.go.th/th/ Filedownload/ Nci%20 Cancer%20Registry-Cancer%20in%20thailand_VII.pdf.
5. Cancer Council NSW. Staging and grading bladder cancer. 2014 [Cited September 1, 2014]. Available from http://www.cancercouncil.com.au/80616/b1000/bladder-cancer-10/staging-and-grading-bladder-cancer.
6. Pang KH, Catto JWF. Bladder cancer. Surgery 2013; 31: 523-9.
7. Levy DA. Surveillance for recurrent bladder cancer overview of bladder cancer surveillance. 2015. [Cited January 5, 2017]. Available from http://emedicine.medscape.com/article/458825-overview
8. Bajorin DF. Tumors of kidney, bladder, ureters and renal pelvis. In Goldman L, Ausiello DA, editor. Cecil medicine. (23rded). Philadelphia: Saunders Elsevier, 2008:1303- 9.
9. American Cancer Society. Bladder cancer. 2015. [Cited July 22, 2015]. Available from http://www.cancer.org/acs/groups/cid/documents/webcontent/003085-pdf.pdf.
10. Vuttanon N, Vichittragoonthavon S, Chaisurin P, Thingchai C. Symptom management for bladder cancer in Thailand. Int J Urol Nurs 2017; 11: 82-9.
11. Decaestecker K, Oosterlinck W. Managing the adverse events of intravesical bacillus Calmette-Guerin therapy. Res Rep Urol 2015; 7:157-63.
12. Brausi M, Oddens J, Sylvester R, Bono A, van de Beek C, van Andel G, et al. Side effects of Bacillus Calmette-Guérin (BCG) in the treatment of intermediate- and high-risk Ta, T1 papillary carcinoma of the bladder: results of the EORTC genito-urinary cancers group randomised phase 3 study comparing one-third dose with full dose and 1 year with 3 years of maintenance BCG. Eur Urol 2014; 65:69-76.
13. Goedendorp MM, Gielissen MF, Verhagen CA, Bleijenberg G. Development of fatigue in cancer survivors: a prospective follow-up study from diagnosis into the year after treatment. J Pain Symptom Manage 2013; 45:213-22.
14. Lenz ER, Pugh LC, Milligan RA, Gift A, Suppe F. The middle-range theory of unpleasant symptoms: an update. Adv Nurs Sci 1997; 19:14-27.
15. Jimenez A, Madero R, Alonso A, Martinez-Marin V, Vilches Y, Martinez B, et al. Symptom clusters in advanced cancer. J Pain Symptom Manage 2011; 42:24-31.
16. Kurtz M, Kurtz JC, Given CW, Given B. Symptom cluster among cancer patients and effects of an educational symptom control intervention. Cancer Ther 2007; 5:105-12.
17. Honea N, Brant J, Beck SL. Treatment-related symptom clusters. Semin Oncol Nurs 2007; 23:142-51.
18. Ryu E, Kim K, Cho MS, Kwon IG, Kim HS, Fu MR. Symptom clusters and quality of life in Korean patients with hepatocellular carcinoma. Cancer Nurs 2010; 33: 3-10.
19. Phligbua W, Pongthavornkamol K, Knobf TM, JUnda T, Viwatwongkasem C, Srimuninnimit V. Symptom Clusters and Quality of Life in Women with Breast Cancer Receiving Adjuvant Chemotherapy. Pacific Rim Int J Nurs Res 2013; 17: 249-67.
20. Kwekkeboom KL. Cancer symptom cluster management. Semin Oncol Nurs 2016; 32: 373-82.
21. Miaskowski C, Dunn L, Ritchie C, Paul SM, Cooper B, Aouizerat BE, et al. Latent class analysis reveals distinct subgroups of patients based on symptom occurrence and demographic and clinical characteristics. J Pain Symptom Manage 2015; 50: 28-37.
22. Yates P, Miaskowski C, Cataldo JK, Paul SM, Cooper BA, Alexander K, et al. Differences in Composition of symptom clusters between older and younger oncology patients. J Pain Symptom Manage 2015; 49: 1025-34.
23. Teunissen S, Wesker W, Kruitwagen C, de HAes HC, Voest EE, de Graeff A. Symptom prevalence in patients with incurable cancer: a systematic review. J Pain & Symptom Manage 2007; 34: 94-104.
24. Poole K, Froggatt K. Loss of weight and loss of appetite in advanced cancer: a problem for the patient, the cancer, or the health professional? Palliat Med 2002; 16: 499-506.
25. Stepanski EJ, Walker MS, Schwarzberg LS, Blakely J, Ong JC, Hout AC. The relation of trouble sleeping, depressed mood, and fatigue in patients with cancer. J Clin Sleep Med 2009; 5: 132-6.
26. Roscoe JA, Kaufman ME, Matteson-Rusby SE, Palesh OG, Ryan JL, Kohli S, et al. Cancer-Related Fatigue and Sleep Disorders. The Oncologist 2007; 12: 35-42.
27. Zucca AC, Boyes AW, Linden W, Girgis A. All's well that ends well? Quality of life and physical symptom clusters in long-term cancer survivors across cancer types. J Pain Symptom Manage 2012; 43: 720-31.
28. Jacobsen PB, Andrykowski MA. Tertiary prevention in cancer care: understanding and addressing the psychological dimensions of cancer during the active treatment period. Am Psychol 2015; 70: 134-5.
29. Jones MP, Dilley JB, Drossman D, Crowell, MD. Brain-gut connections in functional GI disorders: anatomic and physiologic relationships. Neurogastroenterol Motil 2006; 18: 91-103.
30. Vichaya EG, Chiu GS, Krukowski K, Lacourt TE, Kavelaars A, Dantzer R, et al. Mechanisms of chemotherapy-induced behavioral toxicities. Front Neurosci 2015; 9: 131.
31. Skerman HM, Yates PM, Battistutta D. Identification of cancer-related symptom clusters: an empirical comparison of exploratory factor analysis methods. J Pain Symptom Manage 2012; 44:10-22.
32. Stein A, Voigt W, Jordan K. Chemotherapy-induced diarrhea: pathophysiology, frequency and guideline-based management. Ther Adv Med Oncol 2010; 2:51-63.
33. Gibson RJ, Stringer AM. Chemotherapy-induced diarrhea. Curr Opin Support Palliat Care 2009; 3:31-5.
34. Boltong A, Aranda S, Keast R, Wynne R, Francis PA, Chirgwin J, et al. A prospective cohort study of the effects of adjuvant breast cancer chemotherapy on taste function, food liking, appetite and associated nutritional outcomes. PLoS ONE 2014; 9: e103512.
35. Stanton AL, Rowland JH, Ganz PA. Life after diagnosis and treatment of cancer in adulthood: contributions from psychosocial oncology research. Am Psychol 2015; 70: 159-74.
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Published
2018-08-21
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Vuttanon N, Finnegan L, Chaisurin P. Symptom Clusters in Patients with Bladder Cancer: A Secondary Analysis. SRIMEDJ [Internet]. 2018 Aug. 21 [cited 2024 Nov. 25];33(5):431-7. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/141471
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