Vitamin D Deficiency and the Risk of Osteoporosis in Elderly Women
Main Article Content
Backgroud : Vitamin D deficiency lead to elevations in parathyroid hormone levels, resulting in increased bone resorption and reduced BMD, especially cortical bone, and caused skeletal osteoporosis. Up to now there are very few studies to show the effect of vitamin D deficiency on bone mineral density. The level of vitamin D deficiency vary considerably with latitude, also the variability in the different vitamin D assays, that varies from 10 – 40 ng/ml. From our previous study about prevalence of vitamin D deficiency, it being found that the level of calcidiol < 35 ng/ml was th level of vitamin D deficiency.
Objective : To determine the risk of osteoporosis in lumbar spine, proximal femur and the distal radius, between the elderly women with and without vitamin D deficiency.
Design : Cross – sectional descriptive study.
Setting : Municipality of Khon Kaen province, Thailand.
Outcome Measurements : Serum calcidiol and PTH levels and bone mineral density of lumbar spine, proximal femur and distal forearm.
Results : No any significant difference in age, weight, height, BMI and the alkaline phosphatase level between both groups. There was only PTH level that showed significant difference between both groups. A calcudiol level of < 35 ng/ml was associated with an increased in the risk of osteoporosis of femoral neck with the odds ratio (95%CI) of 2.87 (1.15;7.15), p = 0.02. But no any risks in other parts of the skeletons.
Conclusion : Vitamin D deficiency increased the risk of osteoporosis of the femoral neck.
Key words : Vitamin D deficiency, elderly women, odds ratio, femoral neck.