Risk Factors Associated With Allergic To Non – Ionic Contrast Media In Patients Undergoing Chest Or Abdominal Computed Tomography

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Sangiam Chartrapong
Jiraporn Srinakarin
Yamuna Summart
Sumon Direkrit


Background: The use of non – ionic contrast media is favored by many imaging modalities

because, supposedly, it has putatively fewer complication.

Objective: To study risk factors that  are associated with allergic reaction to non – ionic contrast media in patients undergoing chest or abdominal computed tomography.

Design: Descriptive study.

Setting: Diagnostic Radiology Unit, Srinagarind Hospital, Faculty of Medicine,Khon Kaen


Intervention: Prospective study between December 2001 and May 2002 of 1,064  patients

undergoing chest or abdominal computed tomography (CT) and receiving intravenous, non- ionic contrast media Iopamidol 300 or Iopromide 300 .

Measurement: Adverse effect during administration of any  non- ionic intravenous contrast media.

Result: No statistically significant difference was found between the kind of media, amount or method of  injection of either non –ionic contrast media ( p =0.298, 0.082  and 0.911). No statistically significant  adverse affect was found related to  any  underlying disease i.e. heart disease (37/1,064), allergy (58/1,064), asthma (31/1,064), hypertension (95/1,064), and diabetes mellitus (89/1,064) (p= 0.423, 0.846, 0.299, 0.955, 0.620, respectively) except a history of seafood allergy ( p < 0.05).

Conclusion: A history of seafood allergy is the only risk factor associated with allergic reaction to the non- ionic contrast media.


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