The Effects of Monosodium Glutamate Consumption on Oral Glucose Tolerance Test (OGTT) in Rats

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Piyanard Boonnate
Supattra Pethlert
Amod Sharma
Wiphawi Hipkaeo
Sakda Waraasawapati
Vitoon Prasongwattana
Ubon Cha'on

Abstract

Background and Objective: Monosodium glutamate (MSG) is a sodium salt of glutamic acid, widely used as a food additive both in household and food industry. An injection of MSG into newborn mice causes of several metabolic disorders such as obesity, non-alcoholic fatty liver disease and type 2 diabetes. We aimed to investigate the effect of MSG consumption on glucose regulation in adult rats.

Methods: Twenty adult male Wistar rats were randomly divided into control and treatment groups. Both groups were fed ad libitum with a standard rat chow pellet and water, except the treatment group were received MSG (2 mg/g body weight/day) in drinking water for nine months. Oral glucose tolerance tests (OGTT) were investigated. Water intake, food intake and body weight were also recorded.

Results: There were no significant differences in OGTT results between control and MSG-treated animals. MSG-treated rats had significantly higher water intake compared to controls. However there were no significant differences in food intake and body weight between control and MSG-treated animals.

Conclusion: The results revealed that daily MSG consumption with the dose of 2 mg/g body weight /day for nine months had no effect on OGTT, an index of glucose regulation, in adult rats.

Key words: monosodium glutamate, oral glucose tolerance test, islets of Langerhans

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1.
Boonnate P, Pethlert S, Sharma A, Hipkaeo W, Waraasawapati S, Prasongwattana V, Cha’on U. The Effects of Monosodium Glutamate Consumption on Oral Glucose Tolerance Test (OGTT) in Rats. Srinagarind Med J [Internet]. 1 [cited 2021Oct.28];28(4):276-8. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/14892
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