The Effects of Monosodium Glutamate Consumption on Oral Glucose Tolerance Test (OGTT) in Rats

Authors

  • Piyanard Boonnate
  • Supattra Pethlert
  • Amod Sharma
  • Wiphawi Hipkaeo
  • Sakda Waraasawapati
  • Vitoon Prasongwattana
  • Ubon Cha'on

Abstract

Background and Objective: Monosodium glutamate (MSG) is a sodium salt of glutamic acid, widely used as a food additive both in household and food industry. An injection of MSG into newborn mice causes of several metabolic disorders such as obesity, non-alcoholic fatty liver disease and type 2 diabetes. We aimed to investigate the effect of MSG consumption on glucose regulation in adult rats.

Methods: Twenty adult male Wistar rats were randomly divided into control and treatment groups. Both groups were fed ad libitum with a standard rat chow pellet and water, except the treatment group were received MSG (2 mg/g body weight/day) in drinking water for nine months. Oral glucose tolerance tests (OGTT) were investigated. Water intake, food intake and body weight were also recorded.

Results: There were no significant differences in OGTT results between control and MSG-treated animals. MSG-treated rats had significantly higher water intake compared to controls. However there were no significant differences in food intake and body weight between control and MSG-treated animals.

Conclusion: The results revealed that daily MSG consumption with the dose of 2 mg/g body weight /day for nine months had no effect on OGTT, an index of glucose regulation, in adult rats.

Key words: monosodium glutamate, oral glucose tolerance test, islets of Langerhans

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How to Cite

1.
Boonnate P, Pethlert S, Sharma A, Hipkaeo W, Waraasawapati S, Prasongwattana V, Cha’on U. The Effects of Monosodium Glutamate Consumption on Oral Glucose Tolerance Test (OGTT) in Rats. SRIMEDJ [Internet]. 2013 Nov. 27 [cited 2024 Oct. 10];28(4):276-8. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/14892