Drug Interaction Consideration in HIV/HCV Coinfected Patients
Keywords:
HIVAbstract
Nowadays the direct-acting antivirals (DAAs) are in Thailand National List of Essential Medicines (NLEM) for chronic hepatitis C virus (HCV) infection, which results in a more than 95% cure rate. Thus, most hepatitis C patients can now be cured. Patients with HIV/HCV coinfection have a higher mortality risk than Human Immunodeficiency Virus (HIV) infected patients without HCV infections. HIV and HCV coinfected patients require both antiretroviral therapy and antiviral treatment simultaneously. However, health care providers should aware of potential drug interactions among antiretrovirals and antiviral agents in the treatment of HIV and HCV coinfection. The main mechanism of drug interactions occurs during the metabolism process via cytochrome P450 between protease inhibitors or non-nucleoside reverse transcriptase inhibitors and direct-acting antivirals, consequently leading to drug toxicity or treatment failure. Concurrent treatment should be avoided if there are major drug interactions. However, close monitoring or dosage adjustment is sufficient in the case of minor drug interactions. This review article will be useful for healthcare personnel for drug interaction management in order to prevent drug toxicity or treatment failure to ensure that HIV/HCV coinfected patients get the most effective treatment.
References
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25. Wyles DL, Brau N, Kottilil S and et a. Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Patients Co-infected with HCV and HIV-1: The Phase 3 ASTRAL-5 Study Abstract PS104. In: International Liver Congress 2016, Barcelona, Spain, 2016, April 13-17.
26. Fleischer R, Boxwell D and Sherman KE. Nucleoside Analogues and Mitochondrial Toxicity. Clin Infect Dis 2004; 38: e79-e80.
27. Alvarez D, Dieterich DT, Brau N, Moorehead L, Ball L and Sulkowski MS. Zidovudine use but not weight‐based ribavirin dosing impacts anaemia during HCV treatment in HIV‐infected persons. J Viral Hepat 2006; 13: 683-9.
28. Panel on Antiretroviral Guidelines for Adults and Adolescents. Department of Health and Human Services. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. [Cited June 14, 2018]. Available from: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf
29. University of Liverpool. Hep drug interactions. [Cited June 14, 2018]. Available from: https://www.hep-druginteractions.org/checker .
2. Ledinghen Vd, Barreiro P, Foucher J, Labarga P, Castera L, Vispo ME, et al. Liver fibrosis on account of chronic hepatitis C is more severe in HIV-positive than HIV-negative patients despite antiretroviral therapy. J Viral Hepat 2008; 15: 427-33.
3. WHO. Hepatitis C. [Cited June 14, 2018]. Available from: http://www.who.int/news-room/fact-sheets/detail/hepatitis-c.
4. Cope R, Pickering A, Glowa T, Faulds S, Veldkamp P and Prasad R. Majority of HIV/HCV Patients Need to Switch Antiretroviral Therapy to Accommodate Direct Acting Antivirals. AIDS Patient Care and STDs 2015; 29: 379-383.
5. Akekawatchai C, Sretapunya W, Pipatsatitpong D and Chuenchit T. Hepatitis B or C virus coinfection in and risks for transaminitis in human immunodeficiency virus - infected Thais on combined antiretroviral therapy. Asian Biomed 2017; 9: 353-361.
6. Martinello M, Dore GJ, Skurowski J, Bopage RI, Finlayson R, Baker D, et al. Antiretroviral Use in the CEASE Cohort Study and Implications for Direct-Acting Antiviral Therapy in Human Immunodeficiency Virus/Hepatitis C Virus Coinfection. Open Forum Infect Dis 2016; 3: 1-8. Thai Association for the Study of the Liver. Thailand Practice Guideline for Management of Chronic Hepatitis C 2018. Thai Association for the Study of the Liver, 2018.
8. AASLD and IDSA. HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C. [Cited June 14, 2018]. Available from: https://www.hcvguidelines.org/unique-populations/hiv-hcv.
9. Rice DP FJ, Banks S and Chirch LM. HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals. J Clin Transl Hepatol 2016; 4: 234-40.
10. Bifano M, Hwang C, Oosterhuis B, Hartstra J, Grasela D, Tiessen R, et al. Assessment of pharmacokinetic interactions of the HCV NS5A replication complex inhibitor daclatasvir with antiretroviral agents: ritonavir-boosted atazanavir, efavirenz and tenofovir. Antivir Ther 2013; 18: 931-40.
11. Lexicomp. Lexicomp Drug Interaction. Waltham, MA: UpToDate Inc., 2018.
12. Luetkemeyer AF, McDonald C, Ramgopal M, Noviello S, Bhore R and Ackerman P. 12 Weeks of Daclatasvir in Combination With Sofosbuvir for HIV-HCV Coinfection (ALLY-2 Study): Efficacy and Safety by HIV Combination Antiretroviral Regimens. Clin Infect Dis 2016; 62: 1489-96.
13. Wyles DL, Ruane PJ, Sulkowski MS, Dieterich D, Luetkemeyer A, Morgan TR, et al. Daclatasvir plus Sofosbuvir for HCV in Patients Coinfected with HIV-1. NEJM 2015; 373: 714-25.
14. แนวทางการตรวจรักษาและป้องกันการติดเชื้อเอชไอวีและโรคติดต่อทางเพศสัมพันธ์ ประเทศไทย ปี 2560 (Thailand National Guidelines on HIV/AIDS Treatment and Prevention 2017). กรุงเทพฯ: กรมควบคุมโรค กระทรวงสาธารณสุข, 2560.
15. Kirby B, Mathias A, Rossi S, Moyer C, Shen G and Kearney BP. GS-7977 & HIV ARTs PK - No Clinically Significant Pharmacokinetic Interactions Between Sofosbuvir (GS-7977) and HIV Antiretrovirals Atripla, Rilpivirine, Darunavir/Ritonavir, or Raltegravir in Healthy Volunteers. In: 63rd Annual Meeting of the American Association for the Study of Liver Diseases Boston, MA, Nov 9-12, 2012.
16. Garrison K, Custodio J and Pang P. Drug-interactions between anti-HCV antivirals ledipasvir/sofosbuvir and integrase strand transfer inhibitor-based regimens [Abstract 71]. In: 16th International Workshop on Clinical Pharmacology of HIV and Hepatitis Therapy Washington, DC, May 26–28, 2015.
17. Lucas GM, Ross MJ, Stock PG, Shlipak MG, Wyatt CM, Gupta SK, et al. Executive Summary: Clinical Practice Guideline for the Management of Chronic Kidney Disease in Patients Infected With HIV: 2014 Update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 2014; 59: 1203-7.
18. Osinusi A, Townsend K, Kohli A and et al. Virologic response following combined ledipasvir and sofosbuvir administration in patients with hcv genotype 1 and hiv co-infection. JAMA 2015; 313: 1232-9.
19. Naggie S, Cooper C, Saag M, Workowski K, Ruane P, Towner WJ, et al. Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1. NEJM 2015; 373: 705-13.
20. Rockstroh JK, Nelson M, Katlama C and et a. Efficacy and safety of grazoprevir (MK-5172) and elbasvir (MK- 8742) in patients with hepatitis C virus and HIV co-infection (C-EDGE CO-INFECTION): a non-randomised, open-label trial. Lancet HIV 2015; 2: e319-27.
21. Feng HP, Caro L, Dunnington KM, Guo Z, Cardillo-Marricco N, Wolford D, et al. A clinically meaningful drug-drug interaction observed between Zepatier (Grazoprevir/Elbasvir) and Stribild HIV fixed dose combination in healthy subjects [Abstract O-22]. In: International Workshop on Clinical Pharmacology of HIV & Hepatitis Therapy, June 8-10, 2016.
22. MERCK & CO., Inc. ZEPATIER: elbasvir and grazoprevir [prescription information]. Whitehouse station, NJ: MERCK & CO.,INC., 2018.
23. Gilead Sciences, Inc. Epclusa: sofosbuvir and velpatasvir [prescribing information]. Foster city, CA: Gilead Sciences, Inc., 2016.
24. Mogalian E, German P, Kearney BP, Yang CY, Brainard D, McNally J, et al. Use of Multiple Probes to Assess Transporter- and Cytochrome P450-Mediated Drug–Drug Interaction Potential of the Pangenotypic HCV NS5A Inhibitor Velpatasvir. Clin Pharmacokinet 2016; 55: 605-13.
25. Wyles DL, Brau N, Kottilil S and et a. Sofosbuvir/Velpatasvir Fixed Dose Combination for 12 Weeks in Patients Co-infected with HCV and HIV-1: The Phase 3 ASTRAL-5 Study Abstract PS104. In: International Liver Congress 2016, Barcelona, Spain, 2016, April 13-17.
26. Fleischer R, Boxwell D and Sherman KE. Nucleoside Analogues and Mitochondrial Toxicity. Clin Infect Dis 2004; 38: e79-e80.
27. Alvarez D, Dieterich DT, Brau N, Moorehead L, Ball L and Sulkowski MS. Zidovudine use but not weight‐based ribavirin dosing impacts anaemia during HCV treatment in HIV‐infected persons. J Viral Hepat 2006; 13: 683-9.
28. Panel on Antiretroviral Guidelines for Adults and Adolescents. Department of Health and Human Services. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV. [Cited June 14, 2018]. Available from: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf
29. University of Liverpool. Hep drug interactions. [Cited June 14, 2018]. Available from: https://www.hep-druginteractions.org/checker .
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Published
2018-10-06
How to Cite
1.
Akanit U. Drug Interaction Consideration in HIV/HCV Coinfected Patients. SRIMEDJ [Internet]. 2018 Oct. 6 [cited 2024 Nov. 21];33(6):615-22. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/149339
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