Association Between VDR (Tru91) Polymorphism and Cervical Cancer Risk among Women in Northeast Thailand

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Chatchaya Dolprasit
Wannapa Settheetham-Ishida
Sitakan Natphopsuk
Danai Tiwawech
Dariwan Settheetham

Abstract

Background and Objectives:  Tru91 is a vitamin D receptor gene (VDR), plays a crucial role in cancer development. There are three genotypes of VDR (Tru91) including GG, GA and AA genotype. This genetic polymorphism of VDR (Tru91) might be associated with the cancer risk, however, it has never been performed in Thailand. Therefore, the purpose of this study was to investigate the association between VDR (Tru91) polymorphism and cervical cancer risk in the Northeastern Thailand.

Methods:  An aged matched case-control study conducted 175 invasive cervical cancer patients and 175 healthy controls. Blood samples were collected for DNA extraction and VDR (Tru91) genotype was analyzed by using real-time polymerase chain reaction method. Then, the association between VDR (Tru91) polymorphism and the risk of cervical cancer was determined among Northeastern Thai women by using logistic regression.

Results:  Prevalence of GG, GA and AA was 96, 9 and 70 in the controls, respectively; 104, 11 and 60 in the cervical cancer patients, respectively. The association between VDR (Tru91) polymorphism and the risk of cervical cancer was not observed (p>0.05) in Northeastern Thai women. However, in non-users of oral contraceptive pills, the AA genotype was associated with reduction of cervical cancer risk with OR, 0.54 (95%Cl = 0.28-1.03, p=0.043) and adjusted OR, 0.52 (95%Cl=0.28-0.96, p=0.036), compared with GG genotype, whereas the association between VDR (Tru91) polymorphism and the risk of cervical cancer was not observed in oral contraceptive pill users or partner smoking status (p>0.05).

Conclusions:  Our data suggest that VDR (Tru91) polymorphism may not contribute to increase risk for cervical cancer development in the Northeastern Thai women.  

Keywords:  Tru91, VDR, genetic polymorphism, cervical cancer

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