Curcumin Prevents Cardiac Remodeling in L-NAME-Induced Hypertensive Rats

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Parichat Prachaney
Wilaiwan Mothong
Rarinthorn Samrid
Poungrat Pakdeechote
Pattanapong Boonprom
Benyapha Sripanya
Thewarid Berkban

Abstract

Background and Objectives: Curcumin (CUR), a yellow-orange dye obtained from turmeric, has anti-hypertensive, antioxidant, and anti-inflammatory effects.  The present study investigated the effect of curcumin on cardiac remodeling in L-NAME treated rats.


Methods: Male Sprague-Dawley rats weighing 220-240 g were treated with L-NAME (50 mg/kg/day) in drinking water and orally treated with CUR (100 mg/kg per day) for five weeks (n=8/group). Cardiac remodeling indicators, including wall thickness, cross sectional area (CSA), luminal area and fibrosis of the left ventricle (LV) were measured.   


Results: L-NAME-treated rats showed increases in wall thickness, CSA, fibrosis of the LV and a reduction of ventricular luminal area. CUR significantly prevented the development of cardiac remodeling induced by L-NAME in rats (p<0.05).


Conclusion: These data suggested that CUR had cardioprotective effects in L-NAME hypertensive rats.

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How to Cite
1.
Prachaney P, Mothong W, Samrid R, Pakdeechote P, Boonprom P, Sripanya B, Berkban T. Curcumin Prevents Cardiac Remodeling in L-NAME-Induced Hypertensive Rats. SRIMEDJ [Internet]. 2019 Mar. 29 [cited 2024 Feb. 23];34(2):129-33. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/180993
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Original Articles

References

1. Pakdeechote P, Prachaney P, Berkban W, Kukongviriyapan U, Kukongviriyapan V, Khrisanapant W, et al. Vascular and antioxidant effects of an aqueous mentha cordifolia extract in experimental NG-nitro-L-arginine methyl ester-induced hypertension. Z Naturforsch C 2014; 69: 35-45.
2. Berkban T, Boonprom P, Bunbupha S, Welbat JU, Kukongviriyapan U, Kukongviriyapan V, et al. Ellagic acid prevents L-NAME-induced hypertension via restoration of eNOS and p47phox expression in rats. Nutrients 2015; 7: 5265-80.
3. Boonprom P, Boonla O, Chayaburakul K, Welbat JU, Pannangpetch P, Kukongviriyapan U, et al. Garcinia mangostana pericarp extract protects against oxidative stress and cardiovascular remodeling via suppression of p47phox and iNOS in nitric oxide deficient rats. Ann Anat. 2017; 212: 27-36.
4. Maneesai P, Prasarttong P, Bunbupha S, Kukongviriyapan U, Kukongviriyapan V, Tangsucharit P, et al. Synergistic antihypertensive effect of Carthamus tinctorius L. extract and captopril in L-NAME-induced hypertensive rats via restoration of eNOS and AT1R expression. Nutrients 2016; 8: 122.
5. Akram M, Shahab-Uddin AA, Usmanghani K, Hannan A, Mohiuddin E, Asif M. Curcuma longa and curcumin: a review article. Rom J Biol Plant Biol 2010; 55: 65-70.
6. Araujo C, Leon L. Biological activities of Curcuma longa L. Memórias do Instituto Oswaldo Cruz 2001; 96: 723-8.
7. Afkir S, Nguelefack TB, Aziz M, Zoheir J, Cuisinaud G, Bnouham M, et al. Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats: Part I: Cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats. J Ethnopharmacol. 2008; 116: 288-95.
8. Mitsuhata H, Saitoh J, Hasome N, Takeuchi H, Horiguchi Y, Shimizu R. Nitric oxide synthase inhibition is detrimental to cardiac function and promotes bronchospasm in anaphylaxis in rabbits. Shock (Augusta, Ga.) 1995; 4: 143-8.
9. Pechánová O, Bernátová I, Babál P, Martínez MC, Kyselá S, Stvrtina S, et al. Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens. 2004; 22: 1551-9.
10. Simko F, Simko J. The potential role of nitric oxide in the hypertrophic growth of the left ventricle. Physiol Res. 2000; 49: 37-46.
11. Simko F. Physiologic and pathologic myocardial hypertrophy–physiologic and pathologic regression of hypertrophy? Med Hypotheses. 2002; 58: 11-4.
12. Lee DI, Kass DA. Phosphodiesterases and cyclic GMP regulation in heart muscle. Physiology. 2012; 27: 248-58.
13. Nakmareong S, Kukongviriyapan U, Pakdeechote P, Donpunha W, Kukongviriyapan V, Kongyingyoes B, et al. Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension. Naunyn Schmiedebergs Arch Pharmacol. 2011; 383: 519.