Curcumin Prevents Cardiac Remodeling in L-NAME-Induced Hypertensive Rats

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Parichat Prachaney
Wilaiwan Mothong
Rarinthorn Samrid
Poungrat Pakdeechote
Pattanapong Boonprom
Benyapha Sripanya
Thewarid Berkban


Background and Objectives: Curcumin (CUR), a yellow-orange dye obtained from turmeric, has anti-hypertensive, antioxidant, and anti-inflammatory effects.  The present study investigated the effect of curcumin on cardiac remodeling in L-NAME treated rats.

Methods: Male Sprague-Dawley rats weighing 220-240 g were treated with L-NAME (50 mg/kg/day) in drinking water and orally treated with CUR (100 mg/kg per day) for five weeks (n=8/group). Cardiac remodeling indicators, including wall thickness, cross sectional area (CSA), luminal area and fibrosis of the left ventricle (LV) were measured.   

Results: L-NAME-treated rats showed increases in wall thickness, CSA, fibrosis of the LV and a reduction of ventricular luminal area. CUR significantly prevented the development of cardiac remodeling induced by L-NAME in rats (p<0.05).

Conclusion: These data suggested that CUR had cardioprotective effects in L-NAME hypertensive rats.

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How to Cite
Prachaney P, Mothong W, Samrid R, Pakdeechote P, Boonprom P, Sripanya B, Berkban T. Curcumin Prevents Cardiac Remodeling in L-NAME-Induced Hypertensive Rats. SRIMEDJ [Internet]. 2019 Mar. 29 [cited 2024 Feb. 23];34(2):129-33. Available from:
Original Articles


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