Curcumin Prevents Cardiac Remodeling in L-NAME-Induced Hypertensive Rats
Keywords:
curcumin; cardiac remodeling; L-NAMEAbstract
Background and Objectives: Curcumin (CUR), a yellow-orange dye obtained from turmeric, has anti-hypertensive, antioxidant, and anti-inflammatory effects. The present study investigated the effect of curcumin on cardiac remodeling in L-NAME treated rats.
Methods: Male Sprague-Dawley rats weighing 220-240 g were treated with L-NAME (50 mg/kg/day) in drinking water and orally treated with CUR (100 mg/kg per day) for five weeks (n=8/group). Cardiac remodeling indicators, including wall thickness, cross sectional area (CSA), luminal area and fibrosis of the left ventricle (LV) were measured.
Results: L-NAME-treated rats showed increases in wall thickness, CSA, fibrosis of the LV and a reduction of ventricular luminal area. CUR significantly prevented the development of cardiac remodeling induced by L-NAME in rats (p<0.05).
Conclusion: These data suggested that CUR had cardioprotective effects in L-NAME hypertensive rats.
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