Effect of Houttuynia cordata Thunb. Extract in High-Fat Diet-Induced Obese Rats

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Orathai Tunkamnerdthai
Paradee Auvichayapat
Surachat Chaiwiriyakul


Background and Objective: Obesity is a significant health problem and associated with diabetes mellitus, dyslipidemia, and hypertension. Herbal supplementation is considered as a complementary method for obesity control. Therefore, the objective of this study was to investigate the effects of Houttuynia cordata Thunb. extract (HTE) on weight gain, hyperglycemia, insulin resistance, leptin, and dyslipidemia in high-fat diet-induced obese rats.

Methods: Twenty-four male Sprague-Dawley rats were divided into three groups. Each group was fed with different diet for 12 wks. The first group was fed a standard diet of rat chow, the second was fed a high-fat diet (HFD), and the third was fed an HFD containing 1% HTE. Body weight and food intake were measured throughout the study. Adipose tissue weight, blood sugar, insulin, lipid profiles, and leptin were measured after the experiment.

Results: The addition of HTE to the HFD significantly prevented weight gain (p<0.05). In addition, treatment with HTE resulted in a remarkable reduction in adipose tissue weight, blood sugar, insulin resistance, and leptin (p<0.05). The HTE treatment also significantly improved dyslipidemia (p<0.05). However, no statistically significant change in insulin levels was observed after the HTE treatment.

Conclusions: HTE exhibited anti-obesity effect, decreased fat accumulation in adipose tissue, restored hyperglycemia, insulin resistance and dyslipidemia, and reduced leptin in HFD-induced obese rats. Thus HTE is suggested as a possible alternative treatment for obesity.


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