Effect of Exposure to Low-Level Toluene on Learning and Memory in Mice
Keywords:
Toluene Exposure; Learning and Memory; Morris Water Maze TestAbstract
Background and Objective: Focusing on the study of the effects of exposure toluene on brain functions related to learning and memory. To analyze the level of exposure toluene that affect neurological behavior.
Methods: Experimental mice were exposed to different levels of toluene 5 days per week for 4 weeks continuously. The behavior and duration of the swimming mice in the zone that used to have an underwater platform were testing prior and after exposure to toluene by the Morris Water Maze Test. The statistical differences were analyzed by the Paired sample t-test, One-way ANOVA, and Repeated- Measures ANOVA
Result: Experimental mice that exposed to toluene concentration of 50, 100 and 150 ppm. There was a statistically significant difference in learning with control mice at the level of 0.01. The mean swimming duration of the post-control mice was statistically significant at the level of 0.01. Three groups of experimental mice showed no significant difference in the meantime. When analyzing the differences between the groups, it was found that the mean duration of the control and experimental group mice. After exposed to toluene with different tendencies (p <0.01)
Conclusion: Continuous exposure to low concentrations of toluene affects learning and memory in experimental mice. Must be studied clearly in humans. In order to see the health effects of those who need to work And will lead to the determination of appropriate preventive measures.
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