Role of Klebsiella pneumoniae from Stone on Calcium Oxalate Crystal Growth and Aggregation
Keywords:
kidney stone disease, Klebsiella pneumoniae, calcium oxalate, crystal growth, crystal aggregationAbstract
Background and Objective: Klebsiella pneumoniae is a common bacterium isolated from kidney stone. It may play an important role in stone genesis. Therefore, we aimed to investigate the effects of K. pneumoniae on calcium oxalate monohydrate (COM) crystal growth and aggregation.
Methods: K. pneumoniae from stone was used to investigate the COM crystal growth and aggregation in artificial solution. The COM crystal growth and aggregation were evaluated and reported as the delta crystal area and number of crystal aggregates, respectively.
Results: K. pneumoniae can significantly increase the COM crystal growth (p<0.001) and aggregation (p<0.001) when compared to condition without K. pneumoniae.
Conclusion: K. pneumoniae could increase COM crystal growth and aggregation in vitro. However, the effects of K. pneumoniae in the different conditions on COM crystal growth and aggregates should be further investigated.
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