Naringin Improves Vascular Function in Hypertensive Rats
Keywords:
naringin, hypertension, vascular dysfunction Introduction line 12: N-nitro-L-arginine methyl esterAbstract
Background and Objective: Naringin is a flavonoid. The beneficial effects of naringin have been reported including anti-oxidation and anti-inflammation. This study investigated whether naringin could reduce sympathetic nerve-mediated contractile responses in hypertensive rats.
Methods: Male Sprague-Dawley rats were treated with L-NAME 40 mg/kg/day and orally administered with naringin 40 mg/kg/day for five weeks while control rats received distilled water. Blood pressure and vascular function were measured.
Result: Rats received L-NAME had higher blood pressure (155.95 ± 2.55 vs. 100.80 ± 1.75 mmHg) compared to those of control group (p<0.05). Naringin prevents the development of hypertension induced by L-NAME (101.87 ± 3.52 mmHg, p<0.05). Contractile responses to electrical field stimulation (EFS) in mesenteric vascular beds was enhanced in L-NAME group (p<0.05) and these were suppressed in the naringin treated group (p<0.05). The contractile responses to exogenous norepinephrine was not different between groups. Naringin also improved the vasorelaxation responses to acetylcholine (ACh) (p<0.05). These vascular effects of naringin were consistent with raising nitric oxide levels in hypertensive rats (p<0.05).
Conclusion: Naringin prevented the development of hypertension induced by L-NAME. These preventive effects were associated with improvement of vascular function through increasing Nitric oxide metabolites in L-NAME-induced hypertension.
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