Association of Covid-19 Vaccination and SARS-CoV-2 Infection of Post Covid-19 Vaccination in Chumphae District, Khon Kaen Province


  • Kittiporn Amprarat Master student of Master of Public Health Program in Epidemiology, Faculty of Public Health, Khon Kaen University
  • Supot Kamsa-ard Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University
  • Sangduan Kingkoiklang Department of Social Medicine, Chumphae Hospital, Khon Kaen Province


COVID-19 vaccine, SAR-CoV-2infection, COVID-19


Background and Objectives:   Covid-19 is dangerous communicable disease that spread worldwide about 600 million patients were found. Many countries have covid-19 vaccination campaign for herd immunity. However, there has been little known study on the incidence rate and the association with COVID-19 vaccination and SARS-CoV-2 infection, particularly the proportion of SARS-CoV-2 infections after each vaccine dose. The objective of this study was to determine the relationship between COVID-19 vaccination and SARS-CoV-2 infection and the incidence of SARS-CoV-2 infection after COVID-19 vaccination in Chum Phae District, Khon Kaen province.

Method: This was an analytical retrospective cohort study that included individuals aged 18 years up and history of post covid-19 vaccination. A stratified random sampling technique was used to collect data from patient medical records between 2021-2022  involving 354 COVID-19 patients and then follow up to 6 months for RT-PCR results and registered in the COVID-19 patient database at Chumphae Hospital,  Khon Kaen Province. The data were analyzed using a generalized linear model (GLM), and the adjusted relative risk (Adj RR) with a 95% confidence interval (CI) was presented.

Results: The overall incidence rate was 9.3 per 100 people-6 months (95%CI 6.7-12.8), while the incidence of one dose of vaccination was 76.9 per 100 people-6 months (95%CI 44.3-93.3), and the incidence of two doses of vaccination was 4.1 per 100 people-6 months (95%CI 2.3-7.0). Vaccination was also found to be statistically significantly associated with SARS-CoV-2 infection (p<0.001) in which it was found that receiving 1 dose of vaccine (Adj RR = 2.53; 95%CI = 1.40-4.58) and  2 doses of vaccine  (Adj RR = 0.21; 95%CI = 0.10-0.46).

Conclusion: Vaccination was associated with SARS-CoV-2 infection. The incidence of SAR-CoV-2 infection was low in those who received 2 doses of vaccine, while 1 dose of vaccine did not protect against infection of SAR-CoV-2


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How to Cite

Amprarat K, Kamsa-ard S, Kingkoiklang S. Association of Covid-19 Vaccination and SARS-CoV-2 Infection of Post Covid-19 Vaccination in Chumphae District, Khon Kaen Province. SRIMEDJ [Internet]. 2023 Oct. 26 [cited 2024 Jun. 16];38(5):459-6. Available from:



Original Articles