Risk Factors of Metastatic Invasive Ductal Carcinoma in Thai Women at Surin Hospital
Keywords:
breast cancer, pathological finding, axillary lymph node metastasesAbstract
Background and Objective: Breast cancer is the leading cause of cancer death in Thailand. Pathology result affects both treatment and survival outcome which varied by factors of age, hormone receptor type, histopathology of cancer, size of the tumor, and axillary lymph node metastasis including estrogen receptor (ER) with progesterone receptor (PR) and human epidermal growth factor receptor (HER2) receptors status. This study aimed to verify pathological and related factors associated with axillary lymph node metastasis in patients breast cancer.
Methods: A retrospective descriptive study was performed in a group of patients who underwent a total mastectomy in which pathology reported invasive ductal carcinoma from October 2020 to September 2021.
Results: The study group had an average age of 59.01±12.67 years of which 93.81% of these were over 40 years. The average tumor size was 3.66±2.44 cm, HER2 receptor-positive 24.23%, ER/PR receptor-positive 43.3%, and Ki-67 expression (over 20%) was 64.77%. Factors correlated with axillary lymph node metastasis were 1) size of biopsy tissue between 2-5 cm, odds ratio (OR) was 2.16 with 95%CI 1.05-4.44 2) size of biopsy tissue over 5 cm, OR was 4.19 (95%CI 1.55-11.39 and 3) ER/PR receptor-positive, OR was 2.25 with 95%CI 1.09-4.61. While factors of age, positive HER2 receptor, severity of cellular pathology, and Ki-67 expression were not found relationship with axillary lymph node metastasis.
Conclusion: In a group of patients aged over 40 years; the size of the tumor and positive ER/PR receptor increased the risk of axillary lymph node metastasis. However, the severity of cellular pathology, Ki-67 expression, and positive HER2 receptor did not associate with axillary lymph node metastasis.
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