Ginger Juice: Herb to Reduce Nausea and Vomiting from Chemotherapy
Keywords:
Ginger juice, nausea and vomiting, cancer patients, chemotherapyAbstract
This academic article is a review of the literature on cancer, cancer treatment with chemotherapy. The side effects of chemotherapy are nausea and vomiting. The role of ginger juice which helps reduce nausea and vomiting. It was found that 950 ml of ginger juice per day or 1,500 mg per day can reduce nausea and vomiting. The dose is more than 1,500 mg per day it is not effective in reducing nausea and vomiting, but causes side effects. Ginger juice is not effective in reducing nausea and vomiting in patients receiving high doses of Cisplatin. Caution should be exercised when concomitant use of ginger juice with Crizotinib increases the accumulation of Crizotinib, leading to hepatotoxicity. Including caution when using ginger juice with drugs or anticoagulant products, it can increase the risk of bleeding. Therefore, cancer patients receiving chemotherapy should drink ginger juice 30 minutes before receiving chemotherapy.
References
Brown JS, Amend SR, Austin RH, Gatenby RA, Hammarlund EU, Pienta KJ. Updating the definition of cancer. Mol Cancer Res 2023;21(11):1142-7. doi.10.1158/1541-7786
World Health Organization. World Source: Globocan 2020. [Internet] 2021. [Cited May 5, 2023] Available from https://www.who.int/health-topics/cancer#tab=tab-1.
National Cancer Institue. Cancer in Thailand Vol X, 2016-2018. Bangkok: National Cancer Institue, Thailand; 2021.
Medical Record and Databased Cancer Unit. Cancer in Thailand Vol X 2016-2018. Bangkok: Medical Digital Division, National Cancer Institute; 2021.
Databased of Cancer Patients Unit. Hospital-Based Cancer Registry 2020. Bangkok: Medical Digital Division, National Cancer Institute; 2021.
Databased of Cancer Patients Unit. Hospital-Based Cancer Registry 2021. Bangkok: Medical Digital Division, National Cancer Institute; 2022.
Databased of Cancer Patients Unit. Hospital-Based Cancer Registry 2022. Bangkok: Medical Digital Division, National Cancer Institute; 2024.
Markman M. Expert cancer treatment. [Internet] 2022. [Cited May 5, 2023] Available from https://www.cancercenter.com/treatment-options
Swiner C. Understanding cancer-diagnosis and treatment. [Internet] 2022. [Cited May 5, 2023] Available from https://www.webmd.com/cancer/understanding-cancer-treatment
Chanthawong S. Prevention of chemotherapy-induced nausea and vomiting. Srinagarind Med J 2019; 34(1):115-26.
American Cancer Society. Nausea and vomiting. [Internet] 2021. [Cited May 5, 2023] Available from http://www.cancer.org.
Punjaruk W. Physiology of cancer: prospective aspects beyond the 21st Century. Srinagarind Med J 2015;30(2):175-183.
Marray CJL. The global burden of cancer altributable to risk factors, 2010-19: a systematric analysis for the global burden of disease study 2019. Lancet 2022;400(10352):563-91. doi: 10.1016/S0140-6736(22)01438-6.
Varasap P, Jitthavech J, Lorchirachoonkul V. Risk factors for cancer. Journal of Science Ladkrabang 2018;27(2):1-14.
Natprayut M. Factor associated with colorectal cancer in Buayai Hospital, Nakhon Ratchasima Province. Medical Journal of Srisaket Surin Burirum Hospitals 2021;30(1):219-26.
Withayararaphong U. Incident of colon cancer among patient undergoing colonoscopy screening in Satuek District Node, Buri Ram, Thailand. Medical Journal of Srisaket Surin Buriram Hospitals 2024;39(1):89-98.
Laengvejkal A, Janpraparn J. The method for cancer chemotherapy in U-Thong Community Hospital. Reg 6-7 Med J 2007;26(3):317-29.
Yuphet K, Sangthawee P, Utchariyaprasit E. Nursing management for nutritional improvement of cancer patients. Siritaj Medical Bulletin 2020;13(2):133-40.
Aapro M, Jordan K, Feyer P. Pathophysiology of chemotherapy-induced nausea and vomiting. London: Springer Healthcare; 2015.
Panitkulchai B. Ginger for health. Isan J Pharm Sci 2008;4(1):1-15.
Sakpetch A, Thiemthieprat P, Pattamadilok D. Qualitative and quantitative analysis of ginger rhizome using Ultra Performance Liquid Chromatographic Technique. J Thai Trad Alt Med 2019;17(3):376-89.
Suphat S. Effectiveness of ginger as herb for reducing nausea. Department of Clinical Pharmacy. Khon Kaen: Faculty of Pharmacy, Khon Kaen University; 2016.
Memon N. How do you use ginger for nausea? ginger health benefits. [Internet] 2022. [Cited May 5, 2023] Available from http://www.medicinenet.com/how_do_you_use_ginger_for_nausea/article.htm
Wong C. Ginger for Nausea Relief. [Internet] 2020. [Cited May 5, 2023] Available from https://www.verywellhealth.com/ginger-for-nausea-relief-89214
Suttiwanich S, Khampiew A. Comparison of nausea and vomiting among patients whose receiving antimesis drug with ginger in cancer patients receiving AC and FAC formulations, Lopburi Cancer Hospital. Journal of The Department of Medical Services 2020;45(4):162-6.
Kongmauk S,Changmai S, Hinchiranun S. The Outcomes of supportive nursing pattern and utilization of ginger capsule in reducing nausea and vomiting in breast cancer patients receiving chemotherapy. Christian University Journal 2013;19(1):75-88.
Utane M, Maneesorn J. Effect of ginger powder drinking on nausea and vomiting in cancer patient’s receiving chemotherapy in male surgical ward 2. Chiangrai Med J 2019;11(2):52-9.
Ryan J, Heckler C, Roscoe J, Dakhil S, Kirshner J, Flynn P, et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Supportive Care In Cancer 2012;20(7):1479-89.
Crichton M,Marshall S, Marx W, McCarthy AL, Isenring E. Efficacy of ginger (Zingiber officinale) in ameliorating chemotherapy-induced nausea and vomiting and chemotherapy-related outcomes: A systematic review update and meta-analysis. J Acad Nutr Diet 2019;19(12):2055-68.
Sanaati F, Najafi S, Kashaninia Z, Sadeghi M. Effect of ginger and chamomile on nausea and vomiting caused by chemotherapy in Iranian women with breast cancer. Asian Pac J Cancer Prev 2016;17(8):4125-9.
Ernst E. Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth 2000;84(3):367-71.
Arslan M, Ozdemir L. Oral intake of ginger for chemotherapy-induced nausea and vomiting among woman with breast cancer. Clin J Oncol Nurs 2015;19(5):E92-7. doi 10.1188/15.CJON.E92-E97
Bossi P,Cortinivis D, Fatigoni S, Rocca M C,Fabi A, Seminara P, et al. A randomized, double-blind, placebo-controlled, multicenter study of a ginger extract in the management of chemotherapy-induced nausea and vomiting (CINV) in patients receiving high- dose cisplatin. Ann Oncol 2017: 28(10):2547-2551. doi 10.1093/annonc/mdx315
Kim S, Kwag E, Yang M, Yoo H. Efficacy and safety of ginger on the side effects of chemotherapy in breast cancer patients: systematic review and meta-analysis. Int J Mol Sci 2022;23(19):11267 doi 10.3390/ijms231911267
Kamdaeng P. Ginger : reduce nausea and vomiting. Journal of Nursing Siam University 2018;19(37)148-60.
Revol B, Gautier-Vevret E, Arrive C, Sam-Lai NF, McLeer-Florin A, Pluchart H, et al. Pharmacokinetic herb-drug interaction between ginger and crizotinib. Br J Clin Pharmacol 2020: 86(9):1892-3. doi 10.1111/bcp.13862
Jiang S, Ren D, Li J, Yuan G, Li H, Xu G, et al. Effects of compound K on hyperglycemia and insulin resistance in rats with type 2 diabetes mellitus. Fitoterapia 2014;95: 58-64. doi 10.1016/jifitote.2014.02.017
Panoff L. Is Ginger a safe and effective treatment for nausea?. [Internet] 2019. [Cited May 5, 2023] Available from https://www.healthline.com/nutrition/ginger-for-nausea
Griffim RM. Ginger. [Internet] 2020. [Cited May 5, 2023] Available from https://www.webmd.com/vitamins-and-supplements/ginger-uses-and-risks
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Srinagarind Medical Journal
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
