Treatment Outcomes of Patients with Cervical Intraepithelial Neoplasia with Loop Electrosurgical Excision Procedure in Yasothon Hospital

Authors

  • Kanjana Nonzee Department of Obstetrics and Gynecology, Yasothon Hospital

Keywords:

treatment outcomes, LEEP, cervical cancer

Abstract

Background and Objective: Yasothon Hospital utilized the loop electrical excision procedure (LEEP) to manage pre-cancerous lesions, typically performed by general obstetrician and gynecologist. Previous studies in Yasothon hospital there was no definite conclusion of the treatment outcomes of LEEP. This study aimed to evaluate the treatment outcomes, determine prevalence and identify factors associated with recurrence after LEEP.

Methods: We conducted a retrospective cohort study. The participants were all women undergoing LEEP in Yasothon hospital between January 2019 - June 2023. Data were collected from medical records.

Results: The mean age of participants was 45.0 year. Most cases were associated with HPV 16 (35.2%) and HPV 18 (16%), with cytology showing CIN 2/3 (66.4%). The histopathology results post LEEP indicated CIN 2/3 (57.6%) of case, with positive margin present in 46.4% and complications in 24.0%. The cytology after LEEP confirmed CIN 2/3 in 25.0% and cervical cancer in 5.7%. Prevalence of the persistence or recurrence was 36.4% (95%CI 26.4, 47.3). Factors significantly associated with recurrence of lesions after LEEP include positive margin and HPV DNA test results. 

Conclusions:  LEEP was good outcome and safety for women in this study. However, caution is advised regarding complications and recurrence screening, particularly in women with a positive margin and HPV DNA test result indicating HPV 16/18, who may require comprehensive follow-up after LEEP.

References

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Published

2024-06-24

How to Cite

1.
Nonzee K. Treatment Outcomes of Patients with Cervical Intraepithelial Neoplasia with Loop Electrosurgical Excision Procedure in Yasothon Hospital. SRIMEDJ [Internet]. 2024 Jun. 24 [cited 2024 Oct. 6];39(3):243-51. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/262739

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Section

Original Articles