Effect of Ethanolic Extract of Carthamus tinctorius on Hemodynamic Changes in L-NAME Hypertensive Rats


  • Patoomporn Prasattong
  • Upa Kukongviriyapan
  • Parichat Prachaney
  • Panot Tangsucharit
  • Poungrat Pakdeechote


Hypertension, L-NAME, Safflower, Carthamus tinctorius


Background and Objective:  Carthamus tinctorius (CT) or Safflower is extensively used as herb in traditional medicine. It has been reported to have a strong antioxidant capacity. This study aimed to investigate whether CT ethanolic extract could improve hemodynamic alterations in L-NAME induced hypertensive rats.

Methods: Male Sprague-Dawley rats received L-NAME (40 mg/kg/day) in drinking water for five weeks to induce hypertension or vehicle to serve as control. Hypertensive rats were treated with CT ethanolic extract (300 mg/kg/day) or quercetin (25 mg/kg/day) for the last 2 weeks. Systolic blood pressure (SP) was monitored using a tail cuff method once a week. At the end of experimental day, the blood pressure (BP), heart rate (HR), hindlimb blood flow (HBF) and hindlimb vascular resistance (HVR) were measured. Plasma malondialdehyde (MDA) was also measured.

Results: Rats treated with L-NAME for five weeks had high blood pressure (BP), heart rate (HR), high hindlimb vascular resistance (HVR), low hindlimb blood flow (HBF) (p<0.05). MDA level were increased in L-NAME hypertensive rat (p<0.05). Treatment with either CT ethanolic extract or quercetin for the last two weeks significantly reduced BP, HR, HVR, and plasma MDA level.

Conclusions: These results suggest that the CT ethanolic extract can alleviate hemodynamic in L-NAME hypertensive rats. These effects are possibly related to its antioxidant capacity.


How to Cite

Prasattong P, Kukongviriyapan U, Prachaney P, Tangsucharit P, Pakdeechote P. Effect of Ethanolic Extract of Carthamus tinctorius on Hemodynamic Changes in L-NAME Hypertensive Rats. SRIMEDJ [Internet]. 2015 Sep. 5 [cited 2024 Apr. 19];30(3):236-41. Available from: https://li01.tci-thaijo.org/index.php/SRIMEDJ/article/view/39300



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