Treatment Outcome of Retinoblastoma in Srinagarind Hospital,10 Years Result

Abstract

Background  and objective: Retinoblastoma is the third common cancer in pedriatric and the prevalence is 1 : 15,000  birth life.The incidence is increasing so many treatments is still developed  to cure this disease.The objective of this study was to evaluate outcome and clinical characteristic of retinoblastoma patients.

Method: A retrospective chart review  of patients who were diagnosed with retinoblastoma and underwent treatment in Srinagarind  Hospital during January 2006 to December 2015.

Results: There is 80 patients (99 eyes), 49were male ( 61%) and 31 were female (39%).Mean age of diagnosis was 2.2 years old (min 2 months, max 9 year).  19 patients (23.8 %) were diagnosed bilateral retinoblastoma. 61 cases (76%) present with leukocoria,27 cases (34.1%) with retinal detachment, 15 cases (18.9%) with exophthalmos, 9 cases (11.4 %) with strabismus and 9 cases (11.4 %) with orbital cellulitis. According to International Classification of Retinoblastoma; 42 eyes (42.4%) were group D  and 28 eyes(28.3%) were group E. 74 eyes were underwent enucleation,6 eyes-exenteration,6eyes-photocoagulation, 4eyes- transpapillary thermotherapy, 14 eyes-cryotherapy, 15 eyes-chemo reduction, 20 eyes-external beam radiation,69 cases-adjuvant systemic chemotherapy,63 cases-combine therapyand 5 cases-refusal treatment. At 1 year follow up: 5 patientsin group E(6.3%) was dead. At 5 year: 15 eyes (15.6%) were successful in globe savage and no recurrent or progression.

Conclusion: Overall 5 year survival is  93.75 %