CYP1A1-m2 Polymorphism and Cervical Cancer Risk in Northeastern Thai Women

Abstract

Background and Objectives: The major causes of cervical cancer are HPV infection, carcinogens, as well as genetic background. CYP1A1 enzyme is encoded by CYP1A1 gene which plays an important role in carcinogen detoxification especially, carcinogen from tobacco smoking and hormonal contraceptives. However, polymorphic nature of CYP1A1 has long been recognized and genetic polymorphisms might susceptibility to cancer risk. The aim of this study was to investigate association between CYP1A1 polymorphism and cervical cancer risk among HPV carriers, passive smokers and contraceptive users in Northeastern Thai women.

Methods: The case-control study subjectswere divided into two groups, cervical cancer group (n=204) and control group (n=204). DNA was extracted from buffy coat. Genotype ofCYP1A1-m2was detected by using real-time PCR. Association betweenCYP1A1-m2genotype and cervical cancer risk was analyzed by using logistic regression.

Results: Association between CYP1A1-m2polymorphism and increased risk for cervical cancer was not statistically significant (p>0.05). The risk of cervical cancer was significantly increased in women with CYP1A1-m2GG genotype who had smoking partner (adjusted OR=4.26, 95%CI=1.05-17.28, p<0.05).  However, CYP1A1-m2polymorphism and cervical cancer risk among contraceptive users and HPV carriers was not observed (p>0.05).

Conclusions: Our results suggest that CYP1A1-m2polymorphism is associated with increased risk for cervical cancer in women who had smoking partner.