Non-toxic Effect of Momordica cochinchinensis Spreng Aril Extract on Reproductive System of Male Mice

Abstract

Background and Objective:Momordica cochinchinensis (MC) Spreng, a tropical plant, has various phytochemical components especially carotenoid and phenolic compounds. Although MC was mostly studied about pharmacological properties, its effects on male reproductive parameters have never been reported. This study aimed to investigate the toxic effects of aril MC on sex hormone, body weight, reproductive organ structures, and sperm quality in male mice.

Methods: ICR male mice were randomly divided into three groups (control, vehicle, and aril MC [1000 mg/kg BW] groups) for 35 consecutive days. At the end of experiment, testosterone level, weights of reproductive organs, sperm quality, and structures of testis and epididymis by using routine light microscope histology were examined.

Results:This study found that weights of body, testis, epididymis, and seminal vesicle, sperm concentration, and testosterone levels in aril MC received mice were not significantly different (P>0.05) as compared to those of control and vehicle groups. Additionally, the damages of histological structure of testicular and epididymal tissues in MC treated group were not observed as compared to the control.

Conclusion:Aril MC extract was not toxic to the reproductive organs of male mice.